210345-06-5

Upstream product

• 195964-65-9 (2S)-5-allyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester 
• 51694-22-5 ortho-nitrophenyl selenocyanate 
• 210345-05-4 (S)-5-(2-Hydroxy-ethyl)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester 

Downstream Products

• 210345-10-1 (2S,5R)-1-(2-Benzyloxy-3-phenyl-pent-4-enoyl)-5-vinyl-pyrrolidine-2-carboxylic acid methyl ester 
• 210345-13-4 (3S,9aR)-6-Benzyloxy-5-oxo-7-phenyl-2,3,5,6,7,9a-hexahydro-1H-pyrrolo[1,2-a]azepine-3-carboxylic acid methyl ester 
• 210345-07-6 5R-vinyl proline methyl ester 

Relevant academic research and scientific papers

A sequential electrochemical oxidation - Olefin metathesis strategy for the construction of bicyclic lactam based peptidomimetics

A sequential electrochemical amide oxidation - ring closing olefin metathesis sequence has been used to overcome problems associated with the synthesis of seven-membered ring lactam containing bicyclic peptidomimetics. The synthesis of several previously unavailable bicyelic lactam building blocks for constructing constrained thyroliberin analogs is described.