210345-13-4

Upstream product

• 210345-10-1 (2S,5R)-1-(2-Benzyloxy-3-phenyl-pent-4-enoyl)-5-vinyl-pyrrolidine-2-carboxylic acid methyl ester 
• 195964-65-9 (2S)-5-allyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester 
• 210345-05-4 (S)-5-(2-Hydroxy-ethyl)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester 
• 210345-07-6 5R-vinyl proline methyl ester 
• 328974-66-9 (2S,5R)-N-tert-butoxycarbonyl-5-vinylpyrrolidine-2-carboxylic acid methyl ester 
• 210345-06-5 (2S,5R)-5-[2-(2-Nitro-phenylselanyl)-ethyl]-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester 

Relevant academic research and scientific papers

A sequential electrochemical oxidation - Olefin metathesis strategy for the construction of bicyclic lactam based peptidomimetics

A sequential electrochemical amide oxidation - ring closing olefin metathesis sequence has been used to overcome problems associated with the synthesis of seven-membered ring lactam containing bicyclic peptidomimetics. The synthesis of several previously unavailable bicyelic lactam building blocks for constructing constrained thyroliberin analogs is described.