21038-75-5

Usage

Uses

Used in Pharmaceutical Industry:
4,4,6-trimethyl-1-(4-nitrophenyl)-3,4-dihydropyrimidine-2(1H)-thione is used as an intermediate in the synthesis of pharmaceutical products due to its potential biological activity and diverse reactivity.
Used in Agrochemical Industry:
4,4,6-trimethyl-1-(4-nitrophenyl)-3,4-dihydropyrimidine-2(1H)-thione is used as a precursor in the development of agrochemicals, such as fungicides and bactericides, due to its antifungal and antibacterial properties.
Used in Anticancer Research:
4,4,6-trimethyl-1-(4-nitrophenyl)-3,4-dihydropyrimidine-2(1H)-thione is used as a potential anti-cancer agent in research studies, as it has been studied for its ability to inhibit the growth of cancer cells.
Used in Antioxidant Applications:
4,4,6-trimethyl-1-(4-nitrophenyl)-3,4-dihydropyrimidine-2(1H)-thione is used as an antioxidant in various applications, as it has been investigated for its potential to protect against oxidative stress and damage.
Used in Enzyme Inhibition:
4,4,6-trimethyl-1-(4-nitrophenyl)-3,4-dihydropyrimidine-2(1H)-thione is used as an inhibitor of enzymes such as tyrosinase, which is involved in the production of melanin, a pigment responsible for skin color and protection against UV radiation.

Upstream product

• 100-01-6 4-nitro-aniline 
• 27248-25-5 4-isothiocyanato-4-methylpentan-2-one 
• 141-79-7 4-methyl-pent-3-en-2-one 
• 333-20-0 potassium thioacyanate 
• 66647-68-5 4-bromo-4-methylpentan-2-one 
• 1147550-11-5 ammonium thiocyanate 

Relevant academic research and scientific papers

New Substituted 1-Aryl-4,4,6-Trimethyl-3,4-Dihydropyrimidine-2-(1H)Thiones; A Metal-Free and Solvent-Free Synthesis, Characterization, and Lymphoid Tyrosine Phosphatase Inhibition Studies

A series of fourteen 3,4-dihydropyrimidine-2-thiones (3a–n) were synthesized by a green protocol, and their structures were characterized by spectroanalytical data. The compounds were obtained in high yields by efficient annulation of mesityl oxide (4-methylpent-3-en-2-one) with anilines in the presence of potassium thiocyanate. The reaction is essentially metal-catalyst- and solvent-free, as mesityl oxide itself is the solvent as well as the reactant. The compounds were tested for their ability to inhibit the lymphoid tyrosine phosphatase PTPN22, and 5 of the 14 compounds exhibited IC50 values in the mid-micromolar range, with the most potent hit being the compound 3d, having a methoxy substituent at the 2-position of the phenyl ring with an IC50 = 18 ± 1 μM, and second most potent compound (3c) with an IC50 value of 45 ± 3 μM, having methyl substituents at both 2- and 4-position of the phenyl ring.

Organometallic Compounds. XI. Chlorotrimethylsilane / Sodium Bromide - A Simple System for the in situ Generation of Bromotrimethylsilane. Reaction with Ketones, Sulfoxides, and Various Oxygen Containing Substrates

Bromotrimethylsilane is generated in situ by the addition of chlorotrimethylsilane (2) to a solution or a suspension of sodium bromide (or LiBr, KBr, MgBr2).The reaction of the in situ generated bromotrimethylsilane with ketones, sulfoxides, γ-butyrolactone, triethyl orthoformate, and trialkyl phosphites is described.