210418-11-4Relevant academic research and scientific papers
Synthesis of optically active allenyltitaniums having axial chirality by the reaction of optically active propargylic compounds with a Ti(O-i-Pr)4/2i- PrMgCl reagent
Okamoto, Sentaro,An, Duk Keun,Sato, Fumie
, p. 4551 - 4554 (1998)
The reaction of a titanium(II) complex (η2-propene)Ti(O-i-Pr)2, generated in situ from Ti(O-i-Pr)4 and 2 equiv of i-PrMgCl, with optically active secondary propargyl phosphate and tertiary propargyl carbonate proceeds with more than 97% chiral transfer, thus providing an efficient and practical method for synthesizing di- and tri-substituted allenyltitaniums with high optical purity.
