210484-26-7

Basic information

• Product Name: 2-{(R)-1-[(S)-2-(4-Hydroxy-phenyl)-1-methylcarbamoyl-ethylcarbamoyl]-3-methyl-butyl}-hex-5-enoic acid tert-butyl ester
• Synonyms: 2-{(R)-1-[(S)-2-(4-Hydroxy-phenyl)-1-methylcarbamoyl-ethylcarbamoyl]-3-methyl-butyl}-hex-5-enoic acid tert-butyl ester
• CAS NO: 210484-26-7
• Molecular Weight: 460.614
• Mol File: 210484-26-7.mol

Chemical Properties

• CAS DataBase Reference: 2-{(R)-1-[(S)-2-(4-Hydroxy-phenyl)-1-methylcarbamoyl-ethylcarbamoyl]-3-methyl-butyl}-hex-5-enoic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{(R)-1-[(S)-2-(4-Hydroxy-phenyl)-1-methylcarbamoyl-ethylcarbamoyl]-3-methyl-butyl}-hex-5-enoic acid tert-butyl ester(210484-26-7)
• EPA Substance Registry System: 2-{(R)-1-[(S)-2-(4-Hydroxy-phenyl)-1-methylcarbamoyl-ethylcarbamoyl]-3-methyl-butyl}-hex-5-enoic acid tert-butyl ester(210484-26-7)

Safety Data

• Hazardous Substances Data: 210484-26-7(Hazardous Substances Data)

Upstream product

• 21800-59-9 (S)-2-amino-3-(4-hydroxyphenyl)-N-methylpropanamide 
• 112245-04-2 (R)-2-(2-(tert-butoxy)-2-oxoethyl)-4-methylpentanoic acid 

Relevant articles and documents

The design, synthesis, and structure-activity relationships of a series of macrocyclic MMP inhibitors

A series of succinate-derived hydroxamic acids incorporating a macrocyclic ring were designed, synthesized, and evaluated as inhibitors of matrix metalloproteinases. The inhibitors were designed based on the published X-ray crystal structure of batimastat (1) complexed with human neutrophil collagenase (MMP-8). The synthesized compounds were shown to inhibit selected MMPs in vitro with low nanomolar potency.