21800-59-9

Upstream product

• 22840-18-2 Carbonic acid benzyl ester 4-((S)-2-benzyloxycarbonylamino-2-methylcarbamoyl-ethyl)-phenyl ester 
• 60-18-4 L-tyrosine 
• 74-89-5 methylamine 
• 20558-91-2 Z-Tyr-NHMe 
• 3417-91-2 L-tyrosine methyl ester HCl 
• 1164-16-5 Z-L-Tyr-OH 
• 29713-96-0 N,O-bis-(benzyloxycarbonyl)-L-tyrosine 
• 1080-06-4 L-Tyr-OMe 

Downstream Products

• 67120-03-0 (S)-3-(4-Hydroxy-phenyl)-N-methyl-2-(3-phenyl-thioureido)-propionamide 
• 944732-36-9 (S)-5-(4'-hydroxylbenzyl)-2,2,3-trimethylimidazolidin-4-one 
• 210484-26-7 2-{(R)-1-[(S)-2-(4-Hydroxy-phenyl)-1-methylcarbamoyl-ethylcarbamoyl]-3-methyl-butyl}-hex-5-enoic acid tert-butyl ester 
• 22839-99-2 N-Benzyloxcarbonyl-β-O-benzyl-Asp-Tyr-methylamid 

Relevant academic research and scientific papers

Enantioselective catalysis over chiral imidazolidin-4-one immobilized on siliceous and polymer-coated mesocellular foams

A highly efficient and enantioselective organocatalyst, imidazolidin-4-one, has been successfully immobilized on siliceous MCF and polymer-coated MCF. The resulting heterogenized catalyst demonstrated excellent catalytic performance and recyclability for

INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF

Provided herein are compounds that inhibit pKal, a serine protease whose activity is responsible for proteolytically cleaving kininogen and generating the potent vasodilator and pro-inflammatory peptide bradykinin, which can lead to painful and debilitating inflammatory attacks (e.g., edema). Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of treating pKal-related diseases and disorders (e.g., edema) with the compounds in a subject, by administering the compounds and/or compositions described herein.

Multivalent polyglycerol supported imidazolidin-4-one organocatalysts for enantioselective Friedel-Crafts alkylations

The first immobilization of a MacMillan's first generation organocatalyst onto dendritic support is described. A modified tyrosine-based imidazolidin-4-one was grafted to a soluble high-loading hyperbranched polyglycerol via a copper-catalyzed alkyne-azide cycloaddition (CuAAC) reaction and readily purified by dialysis. The efficiency of differently functionalized multivalent organocatalysts 4a-c was tested in the asymmetric Friedel-Crafts alkylation of N-methylpyrrole with α,β-unsaturated aldehydes. A variety of substituted enals was investigated to explore the activity of the catalytic system which was also compared with monovalent analogues. The catalyst 4b showed excellent turnover rates and no loss of activity due to immobilization, albeit moderate enantioselectivities were observed. Moreover, easy recovery by selective precipitation allowed the reuse of the catalyst for three cycles.

HETEROGENEOUS CHIRAL CATALYST

The invention provides a heterogeneous catalyst comprising a catalytic group coupled to a mesocellular siliceous foam support. The catalytic group is capable of catalysing a reaction selected from the group consisting of a Friedel-Craft reaction and a Die

PREPARATION, SPECTRAL AND PHYSICOCHEMICAL CHARACTERISTICS OF METHYLAMIDE Nα-PHENYLTHIOCARBAMOYL DERIVATIVES OF NATURALLY OCCURING AMINO ACIDS

The methylamide Nα-phenylthiocarbamoyl derivatives of encoded amino acids II were prepared either by the addition of phenylisothiocyanate to amino acid methylamides or by the treatment of amino acid phenylthiohydantoins (5-alkyl-3-phenyl-2-thioxo-4-imidazolinones) I with methylamine.The derivatives were prepared of 19 amino acids and their melting points, 1H NMR, 13C NMR, mass, ultraviolet and infrared spectra were measured.