21051-75-2Relevant academic research and scientific papers
Sodium cyanide-promoted copper-catalysed aerobic oxidative synthesis of esters from aldehydes
Nowrouzi, Najmeh,Abbasi, Mohammad,Bagheri, Maryam
, (2017/09/30)
A simple and efficient copper-catalysed procedure for oxidative esterification of aldehydes with alcohols and phenols mediated by sodium cyanide, using air as a clean oxidant, is described. A variety of aromatic aldehydes and structurally different alcohols and phenols reacted efficiently, and the product esters were obtained in good to excellent yields under normal atmospheric and solvent-free conditions.
Generally applicable and efficient esterification of aldehydes with alcohols catalyzed by cyclopalladated ferrocenylimine
Ma, Gaizhi,Leng, Yuting,Qiao, Huijie,Yang, Fan,Wang, Shiwei,Wu, Yangjie
, p. 44 - 47 (2014/01/06)
The palladacycle-catalyzed esterification of a variety of aldehydes with alcohols was developed. This reaction allows formation of esters in moderate to excellent yields not only for various aldehydes but also alcohols. In addition, the esterification could proceed well under mild conditions with a low catalyst loading of 0.0625 mol%. Copyright
A simple and convenient method for preparation of carboxylic acid alkyl esters, phenolic and thioesters using chlorodiphenylphosphine/I2 and imidazole reagent system
Nowrouzi, Najmeh,Mehranpour, Abdol Mohammad,Rad, Javad Ameri
experimental part, p. 9596 - 9601 (2011/01/03)
Condensation of carboxylic acids with alcohols, phenols and thiols proceeded smoothly to afford carboxylic acid alkyl esters, phenolic esters and thioesters by using the combination of chlorodiphenylphosphine, imidazole and molecular iodine in refluxing acetonitrile. Esterification with this mixed reagent system gave the corresponding products in excellent yields. The phosphorus-containing byproduct was simply removed from the organic phase by basic aqueous workup without the need for chromatography purification.
Microwave-assisted ester formation using O-alkylisoureas: A convenient method for the synthesis of esters with inversion of configuration
Chighine, Alessandra,Crosignani, Stefano,Arnal, Marie-Claire,Bradley, Mark,Linclau, Bruno
experimental part, p. 4753 - 4762 (2009/10/17)
(Chemical Equation Presented) The formation of carboxylic esters via reaction of carboxylic acids with O-alkylisoureas proceeds in excellent yields with very short reaction times when conducted in a monomode microwave synthesizer. Efficient processes were
Easily prepared azopyridines as potent and recyclable reagents for facile esterification reactions. An efficient modified mitsunobu reaction
Iranpoor, Nasser,Firouzabadi, Habib,Khalili, Dariush,Motevalli, Somayeh
, p. 4882 - 4887 (2008/09/21)
(Chemical Equation Presented) The 2,2′-, 3,3′-, and 4,4′-azopyridines (azpy) and their alkyl pyridinium ionic liquids were studied as a new class of electron-deficient reagents for Mitsunobu esterification reactions. Among these compounds, 4,4′-azopyridine was found to be the most suitable one for esterification and thioesterification reactions. This new reagent promises to provide general and complementary solutions for separation problems in Mitsunobu reactions without restricting the reaction scope and facilitates the isolation of its hydrazine byproduct. The pyridine hydrazine byproduct can be simply recycled to its azopyridine by an oxidation reaction.
Chromatography-free product separation in the Mitsunobu reaction
Proctor, Anthony J.,Beautement, Kevin,Clough, John M.,Knight, David W.,Li, Yingfa
, p. 5151 - 5154 (2007/10/03)
Mitsunobu products can be isolated pure without column chromatography by first washing a solution of the crude reaction mixture in dichloromethane with 15% aqueous hydrogen peroxide followed by aqueous sodium sulfite. A final filtration through silica gel secures the pure Mitsunobu product.
PHOSPHONIUM SALTS DERIVATIVES AND THEIR USE AS SOLUBILITY CONTROLLING AUXILIARIES
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Page/Page column 33, (2010/02/14)
The present invention relates to the use of compounds of formula (IA) or (IIA): insert formula (IA) and (IIA) from page 15 of the disclosure wherein A represents various substituted or unsubstituted groups such as furyl, phenyl, pyridyl, naphthyl, or thiophenyl; X- represents an anion; and L1 represents a linker, as solubility controlling auxiliaries. These compounds can also be used as solubility controlling fragments of a molecule. The invention also relates to various methods of controlling the solubility of a molecule or a substrate. Moreover, the invention also relates to various phosphonium supported reagents or various phosphonium salts derivatives.
