21060-31-1Relevant articles and documents
Discovery of functionalized bisimidazoles bearing cyclic aliphatic-phenyl motifs as HCV NS5A inhibitors
Zhong, Min,Peng, Eric,Huang, Ningwu,Huang, Qi,Huq, Anja,Lau, Meiyen,Colonno, Richard,Li, Leping
, p. 5731 - 5737 (2015/01/08)
This Letter describes the discovery of a number of functionalized bisimidazoles bearing a cyclohexylphenyl, piperidylphenyl, or bicyclo[2,2,2]octylphenyl motif as HCV NS5A inhibitors. Compounds 2c, 4b and 6 have demonstrated low single-digit nM potency in gt-1a replicon and double-digit pM potency in gt-1b replicon, respectively. Moreover, both 4b and 6 have, respectively, exhibited good oral bioavailability in rats with a favorable liver/plasma ratio of the drug concentration.
Aliphatic Liquid Crystals, 9. - Stereospecific Reduction of 1-Acyl- to 1-Alkyl-4-phenylcyclohexanes
Sucrow, Wolfgang,Heider, RRoland,Joraschek, Norbert
, p. 1039 - 1044 (2007/10/02)
The title reaction - important for the synthesis of aliphatic liquid crystals - is accomplished by reduction of the tosylhydrazones with sodium cyanoborohydride.While the trans-configurated model ketones 6a, 7a give the tosylhydrazones 10a, 11a, and these
New phenylcyclohexyl- and cyclohexylphenylamines. Synthesis and pharmacological activity
De Meglio,Carissimi,Ravenna,Gentili
, p. 191 - 202 (2007/10/02)
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