21062-19-1

Upstream product

• 622-75-3 1,4-phenylenediacetonitrile 
• 623-25-6 p-Xylylene dichloride 
• 7325-46-4 1,4-phenylenediacetic acid 

Downstream Products

• 110052-22-7 p-phenylenedi-acetic acid bis-(3-dimethylamino-propyl ester) 
• 115386-51-1 p-phenylenedi-acetic acid bis-(3-diethylamino-propyl ester) 
• 102702-54-5 p-phenylenedi-acetic acid bis-(2-diethylamino-ethyl ester) 
• 115754-34-2 1-Ethyl-3-(2-{4-[2-(3-ethyl-thioureido)-2-oxo-ethyl]-phenyl}-acetyl)-thiourea 
• 115754-31-9 C₂₆H₂₆N₄O₄ 
• 115754-30-8 C₂₆H₂₆N₄O₄ 
• 115754-32-0 C₂₄H₂₀Cl₂N₄O₄ 
• 146231-71-2 N-(4'-Nitro-biphenyl-2-yl)-2-{4-[(4'-nitro-biphenyl-2-ylcarbamoyl)-methyl]-phenyl}-acetamide 
• 139131-52-5 1,4-benzenediacetonenitrile 
• 115754-28-4 {2-[4-(2-Oxo-2-ureido-ethyl)-phenyl]-acetyl}-urea 
• 115754-29-5 1-Methyl-3-(2-{4-[2-(3-methyl-ureido)-2-oxo-ethyl]-phenyl}-acetyl)-urea 
• 115754-35-3 C₂₄H₂₂N₄O₂S₂ 
• 62667-40-7 1.4-Benzoldiperessigsaeure-tert.-butylester 
• 50766-26-2 2,2''-(p-Phenylen)-bis-(3,4-dimethoxyacetophenon) 

Relevant academic research and scientific papers

Recognition of insoluble tartaric acid in chloroform

Simple receptors for the recognition and solubilisation of insoluble tartaric acid in chloroform were designed and synthesised for the first time. Receptors 2 and 3 were successful in solubilising tartaric acid into chloroform forming a 1:1 complex, and w

Cobalt(II)-Catalyzed Stereoselective Olefin Isomerization: Facile Access to Acyclic Trisubstituted Alkenes

Stereoselective synthesis of trisubstituted alkenes is a long-standing challenge in organic chemistry, due to the small energy differences between E and Z isomers of trisubstituted alkenes (compared with 1,2-disubstituted alkenes). Transition metal-catalyzed isomerization of 1,1-disubstituted alkenes can serve as an alternative approach to trisubstituted alkenes, but it remains underdeveloped owing to issues relating to reaction efficiency and stereoselectivity. Here we show that a novel cobalt catalyst can overcome these challenges to provide an efficient and stereoselective access to a broad range of trisubstituted alkenes. This protocol is compatible with both mono- and dienes and exhibits a good functional group tolerance and scalability. Moreover, it has proven to be a useful tool to construct organic luminophores and a deuterated trisubstituted alkene. A preliminary study of the mechanism suggests that a cobalt-hydride pathway is involved in the reaction. The high stereoselectivity of the reaction is attributed to both a π-πstacking effect and the steric hindrance between substrate and catalyst.

The Cooperative Effect of Both Molecular and Supramolecular Chirality on Cell Adhesion

Although helical nanofibrous structures have great influence on cell adhesion, the role played by chiral molecules in these structures on cells behavior has usually been ignored. The chirality of helical nanofibers is inverted by the odd–even effect of methylene units from homochiral l-phenylalanine derivative during assembly. An increase in cell adhesion on left-handed nanofibers and weak influence of cell behaviors on right-handed nanofibers are observed, even though both were derived from l-phenylalanine derivatives. Weak and negative influences on cell behavior was also observed for left- and right-handed nanofibers derived from d-phenylalanine, respectively. The effect on cell adhesion of single chiral molecules and helical nanofibers may be mutually offset.

acyl triazole derivative and its manufacturing method

PROBLEM TO BE SOLVED: To provide a novel acyl triazole derivative that can be synthesized at low cost by a convenient method, has a comparable reactivity to an acid chloride with an amine compound and an alcohol compound, and can be safely handled, and a method of manufacturing the same; the acyl triazole derivative that is useful as a reactant applied to polymerization reaction to be continued; and a monomer comprising the same.SOLUTION: An acyl triazole derivative is shown by formula (1). In the formula, A denotes a substituted arylene group, a 1,3-phenylene group, a bisarylene group, a polycyclic arylene group, an alkylene group or an aralkylene group.

Novel bivalent securinine mimetics as topoisomerase I inhibitors

A series of novel bivalent securinine mimetics incorporating different linkers between C-15 and C-15′ were synthesized and their topoisomerase I (Topo I) inhibitory activities evaluated. It was thus revealed that mimetic R2 incorporating a rigid m-substituted benzene linker exhibits Topo I inhibitory activity three times that of parent securinine. Comprehensive structure-activity relationship analyses in combination with docking studies were used to rationalize the potent activity of these bivalent mimetics. Mechanistic studies served to confirm the deductions arising from docking studies that the active bivalent mimetics not only inhibited complexation between Topo I and DNA but also stabilized the Topo I-DNA complex itself.

RUBBER COMPOSITION AND VULCANIZATION AID

A rubber composition comprising a compound having one or more groups represented by formula (X) and a rubber component is provided. wherein ring W1 represents a cyclic group having at least one selected from the group consisting of —C(═O)— and

Nitrogen positional scanning in tetramines active against HIV-1 as potential CXCR4 inhibitors

The paradigm, derived from bicyclams and other cyclams, by which it is necessary to use the p-phenylene moiety as the central core in order to achieve high HIV-1 antiviral activities has been reexamined for the more flexible and less bulky structures 4, p

TRICYCLIC AMINO CONTAINING COMPOUNDS FOR TREATMENT OR PREVENTION OF SYMPTOMS ASSOCIATED WITH ENDOCRINE DYSFUNCTION

The disclosure provides methods of use of certain compounds that are useful for treating certain symptoms of endocrine disturbances, and in particular those associated with hot flashes.

NMR-based molecular ruler for determining the depth of intercalants within the lipid bilayer. Part I. Discovering the guidelines

The development of "molecular rulers" would allow one to quantitatively locate intercalants within the liposomal bilayer. To this end, we have attempted to correlate the 13C NMR chemical shift of a polarizable "reporter" carbon (e.g., carbonyl) of the intercalant-with the ET(30) polarity it experiences, and with its Angstrom distance from the interface. This requires families of molecules with the same two "reporter carbons" separated by a fixed distance, residing at various depths/polarities within the bilayer. The families studied included 4,4-dialkylcyclohexa-2,5-dienones 1, benzenediacetic esters 15, benzenedipropionic esters 17, 4-alkoxybenzaldehydes 19 and methyl 4-alkoxybenzoates 22. These compounds possessed the following characteristics: (1) a planar backbone; (2) polar/hydrophilic "head" groups; (3) modular hydrophobic tails; (4) large changes in the 13C NMR chemical shift (Δδ) of the reporter atoms with solvent polarity. These studies revealed a fifth requirement, namely: (5) the reporter carbons must not be strongly conjugated, lest it reflect the charge build-up at another site within the conjugated system.

Discovery of small molecule CXCR4 antagonists

In light of a proposed molecular mechanism for the C-X-C chemokine receptor type 4 (CXCR4) antagonist 1 (AMD3100), a template with the general structure 2 was designed, and 15 was identified as a lead by means of an affinity binding assay against the liga