21063-87-6

Usage

Uses

Used in Pharmaceutical Industry:
(11alpha)-11-hydroxypregna-4,6-diene-3,20-dione is used as a synthetic intermediate for the production of corticosteroids, which are essential in the development of anti-inflammatory and immunosuppressive drugs. These drugs are vital for treating various medical conditions such as allergies, asthma, and autoimmune diseases, due to their ability to regulate immune response and reduce inflammation.
Used in Medical Treatments:
(11alpha)-11-hydroxypregna-4,6-dione and its synthetic derivatives are used as active pharmaceutical ingredients in the formulation of medications for treating a variety of medical conditions. Their anti-inflammatory and immunosuppressive properties make them effective in managing symptoms and controlling the progression of diseases related to immune system dysregulation and inflammation.

Upstream product

• 1162-56-7 6-dehydroprogesterone 
• 80-75-1 11-alpha-hydroxyprogesterone 

Downstream Products

• 565-96-8 11α-hydroxy-5β-pregnane-3,20-dione 
• 565-94-6 11α-hydroxy-5β-pregnane-3,20-dione 
• 80-75-1 11-alpha-hydroxyprogesterone 

Relevant academic research and scientific papers

Preparation of tritium labelled compounds. V. A group of steroids by catalytic reduction of unsaturated precursors with tritium gas

A group of Δ4 3 keto steroids was prepared by catalytic reduction of suitable conjugated diene 3 keto precursors with tritium gas. Thus, 11α hydroxy 4 pregnene 3,20 dione 7 3H (I), 20α hydroxy 4 pregnen 3 one 7 3H (II), 6α methyl 4 pregnene 3,11,20 trione 7 3H (III), 17α hydroxy 6α methyl 4 pregnene 3,20 dione 7 3H, acetate (IV), and 17α hydroxy 6 methyl 3H3 16 methylenepregna 4,6 diene 3,20 dione, acetate (V) were prepared from 11α hydroxypregna 4,6 diene 3,20 dione (VI), 20α hydroxypregna 4,6 dien 3 one (VII), 6 methylpregna 4,6 diene 3,11,20 trione (VIII), 17α hydroxy 6 methylpregna 4,6 diene 3,20 dione, acetate (IX), and 17α hydroxy 6 dibromomethylene 16 methylene 4 pregnene 3,20 dione, acetate (X), respectively. In addition, 3α hydroxy 5β pregnane 11,20 dione 3H, cyclic 20 (trimethylene acetal) (XI) was prepared from I via 11α hydroxy 5β pregnane 3,20 dione 7 3H (XII), 5β pregnane 3,11,20 trione 7 3H (XIII) and 3α hydroxy 5β pregnane 11,20 dione 7 3H (XIV).

ORGANIC COMPOUNDS AND PROCESSES

This invention relates to novel ring B-secosteroid transformation products, to processes for their preparation and more particularly to compounds embraced by the following formulae: SPC1Wherein R is --CHO, --COOR 1 or --CH 2 OR 2, in which R 1 is hydrogen or methyl and R 2 is hydrogen or acyl; X is SPC2In which R 2 has the meaning given above, R 3 is hydrogen or lower-alkyl and the alkali metal salts of those compounds wherein R is --COOR 1 in which R 1 is hydrogen. The compounds of the above formulae are anti-inflammatory agents, antiandrogenic agents and central nervous system stimulants.