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80-75-1 Usage


11ALPHA-HYDROXYPROGESTERONE, also known as 11-deoxycorticosterone, is a 11alpha-hydroxy steroid that is a metabolite of progesterone. It is a white to light beige crystalline powder and is characterized by the presence of a hydroxy group at position 11 on the pregn-4-ene-3,20-dione structure.


Used in Pharmaceutical Industry:
11ALPHA-HYDROXYPROGESTERONE is used as a pharmaceutical intermediate for the synthesis of various corticosteroids and progestins. It plays a crucial role in the development of medications used to treat hormonal imbalances, menstrual disorders, and other conditions related to the reproductive system.
Used in Research Applications:
11ALPHA-HYDROXYPROGESTERONE is used as a research compound to study the metabolism of progesterone and its role in various physiological processes. It helps researchers understand the mechanisms of action and potential therapeutic applications of progesterone and its derivatives.
Used in Hormone Replacement Therapy:
11ALPHA-HYDROXYPROGESTERONE is used as a hormone replacement therapy agent for conditions such as menopause, where the levels of progesterone and other hormones decrease. It helps alleviate symptoms associated with hormonal imbalances and supports overall health and well-being.
Used in Fertility Treatments:
11ALPHA-HYDROXYPROGESTERONE is used in fertility treatments to support the normal functioning of the reproductive system. It helps regulate menstrual cycles, promotes ovulation, and enhances the chances of conception in women with fertility issues.
Used in Contraceptive Formulations:
11ALPHA-HYDROXYPROGESTERONE is used as a component in contraceptive formulations to prevent pregnancy by regulating hormonal levels and inhibiting ovulation. It is an essential ingredient in various birth control pills and other contraceptive methods.
Used in Veterinary Medicine:
11ALPHA-HYDROXYPROGESTERONE is used in veterinary medicine to treat hormonal imbalances and reproductive disorders in animals. It helps maintain the overall health and well-being of animals by supporting their reproductive systems and hormonal balance.

Check Digit Verification of cas no

The CAS Registry Mumber 80-75-1 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 8 and 0 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 80-75:
51 % 10 = 1
So 80-75-1 is a valid CAS Registry Number.



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017


1.1 GHS Product identifier

Product name 11α-hydroxyprogesterone

1.2 Other means of identification

Product number -
Other names 11alpha-hydroxyprogesterone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:80-75-1 SDS

80-75-1Relevant articles and documents

Dehalogenation methodof 9-halogenated steroid compound and application


Paragraph 0197-0199, (2021/01/11)

The invention provides a dehalogenation method of a 9-halogenated steroid compound and application, and relates to the technical field of chemical synthesis. The dehalogenation method of the 9-halogenated steroid compound comprises the following steps: reacting a compound I with a hydrogen donor and an azo radical initiator to obtain a 9-dehalogenated product compound II of the 9-halogenated steroid compound. According to the dehalogenation method of the 9-halogenated steroid compound, a hydrogen donor adopts one or a combination of more of hypophosphorous acid and hypophosphite, formic acid and formate, organic silicon hydride, hydrazine compounds or cyclohexene, and an initiator adopts an azo free radical initiator. Reagents such as chromium, divalent chromium salt, trivalent chromium salt or tributyltin hydride which are high in toxicity and cause serious pollution to the environment are not used in the reaction, the method is green and environmentally friendly, the synthesis process is simple, convenient and easy to implement, and the production applicability is improved.

Biotransformation of progesterone by the ascomycete Aspergillus niger N402


, p. 26 - 31 (2018/02/06)

The ability of the ascomyceteAspergillus niger N402 to transform exogenous progesterone was investigated. We found that this strain has steroid-hydroxylating activity and can introduce a hydroxyl group into the progesterone molecule mainly at positions C11(α) and C21 with predominant formation of 21-hydroxyprogesterone (deoxycortone). In addition, formation of 6β,11α-dihydroxyprogesterone was also observed. Studying the effects of the growth medium composition and temperature on progesterone conversion by A. niger N402 showed that the most intense accumulation of 21-hydroxyprogesterone occurred in minimal synthetic medium at 28°C. Increasing the cultivation temperature to 37°C resulted in almost complete inhibition of the hydroxylase activity in the minimal medium. In the complete medium, a similar increase in temperature inhibited 11α-hydroxylase activity and completely suppressed 6β-hydroxylase activity, but it produced no effect on 21-hydroxylating activity.

Selective reduction of 4,6- conjugate diene -3-one steroid compound method


Paragraph 0074-0081, (2019/11/21)

Belonging to the field of chemical pharmacy, the invention relates to a method for selective reduction of 4, 6-conjugated diene-3-one steroid, and solves the problem of low yield in hydrogen reduction. The method mainly includes the steps of: 1) adding the 4, 6-conjugated diene-3-one steroid, a liquid solvent, a catalyst, and a reducing agent hydrogen donor into a reaction kettle, performing nitrogen protection, and carrying out stirring heating till reflux; 2) carry out reflux reaction for 3-10h; 3) at the end of reaction, filtering out the catalyst; 4) distilling the solvent; 5) adding purified water after distillation; and 6) conducting cooling, pumping filtering, washing and drying to obtain a 4-ene-3-steroid crystal.

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