210631-01-9Relevant academic research and scientific papers
An Olefin Metathesis Approach to 36- And 72-Membered Archaeal Macrocyclic Membrane Lipids
Arakawa, Kenji,Eguchi, Tadashi,Kakinuma, Katsumi
, p. 4741 - 4745 (1998)
An olefin metathesis approach, which has been successfully applied to an efficient synthesis of archaeal 36- and 72-membered macrocyclic membrane lipids (1, 2a, and 2b), is reported. In the presence of a Grubbs' ruthenium-alkylidene complex, RuCl2/s
A Unified Approach for the Total Synthesis of cyclo-Archaeol, iso-Caldarchaeol, Caldarchaeol, and Mycoketide
Andringa, Ruben L. H.,Driessen, Arnold J. M.,Minnaard, Adriaan J.,de Kok, Niels A. W.
, p. 17497 - 17503 (2021/06/08)
Ir-catalyzed asymmetric alkene hydrogenation is presented as the strategy par excellence to prepare saturated isoprenoids and mycoketides. This highly stereoselective synthesis approach is combined with an established 13C-NMR method to determine the enantioselectivity of each methyl-branched stereocenter. It is shown that this analysis is fit for purpose and the combination allows the synthesis of the title compounds with a significant increase in efficiency.
Asymmetric synthesis of cyclo-archaeol and β-glucosyl cyclo-archaeol
Ferrer, Catalina,Fodran, Peter,Barroso, Santiago,Gibson, Robert,Hopmans, Ellen C.,Damste, Jaap Sinninghe,Schouten, Stefan,Minnaard, Adriaan J.
, p. 2482 - 2492 (2013/06/05)
An efficient asymmetric synthesis of cyclo-archaeol and β-glucosyl cyclo-archaeol is presented employing catalytic asymmetric conjugate addition and catalytic epoxide ring opening as the key steps. Their occurrence in deep sea hydrothermal vents has been
