2107-22-4Relevant academic research and scientific papers
NOVEL HYDRAZINO-CYCLOBUT-3-ENE-1, 2-DIONE DERIVATIVES AS CXCR2 ANTAGONISTS
-
Page/Page column 35-36, (2010/09/03)
The present invention relates to novel hydrazino-cyclobut-3-ene-1,2-dione compounds of Formula (I) as selective CXCR2 antagonists, pharmaceutical compositions containing the novel compounds, as well as methods for treating or preventing chemokine mediated
Design, synthesis, and evaluation of novel 3-amino-4-hydrazine-cyclobut-3-ene-1,2-diones as potent and selective CXCR2 chemokine receptor antagonists
Liu, Shilan,Liu, Yinhui,Wang, Hongmei,Ding, YiLi,Wu, Hao,Dong, Jingchao,Wong, Angela,Chen, Shu-Hui,Li, Ge,Chan, Manuel,Sawyer, Nicole,Gervais, Francois G.,Henault, Martin,Kargman, Stacia,Bedard, Leanne L.,Han, Yongxin,Friesen, Rick,Lobell, Robert B.,Stout, David M.
scheme or table, p. 5741 - 5745 (2010/04/30)
We describe herein a novel series of 3-amino-4-hydrazine-cyclobut-3-ene-1,2-diones as potent and selective inhibitors against the CXCR2 chemokine receptor and IL-8-mediated chemotaxis of a CXCR2-expressing cell line. Furthermore, these alkyl-hydrazine series inhibitors such as 5b demonstrated acceptable metabolic stability when incubated in human and rat microsomes.
Hydrazinocarbonyl-thieno[2,3-C]pyrazoles, Process for Preparing Them, Compositions Containing Them and Use Thereof
-
Page/Page column 39, (2008/12/06)
The present invention concerns hydrazinocarbonyl-thieno[2,3-c]pyrazoles of formula (I): wherein R1, R3, R4, are R5 are as defined in the disclosure; their preparation method, compositions containing the same and their use for the treatment of pathological conditions, in particular as anticancer agents.
