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N-ethyl-N-(4-fluorophenyl)nitrous amide, also known as EFNA, is a chemical compound with the molecular formula C9H10FN2O. It is a nitroso amide derivative, characterized by the presence of a nitroso group (-N=O) and an amide group (-CO-NH2). EFNA is a potent and selective agonist of the metabotropic glutamate receptor 2 (mGlu2), which plays a crucial role in the central nervous system. It is primarily used in scientific research to study the effects of mGlu2 receptor activation on various neurological processes, such as synaptic transmission, neuronal excitability, and neuroprotection. Due to its specific receptor binding, EFNA has potential therapeutic applications in the treatment of neurological disorders, including anxiety, depression, and neurodegenerative diseases. However, it is important to note that EFNA is a research chemical and not approved for clinical use.

2707-17-7

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2707-17-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 2707-17-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,7,0 and 7 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 2707-17:
(6*2)+(5*7)+(4*0)+(3*7)+(2*1)+(1*7)=77
77 % 10 = 7
So 2707-17-7 is a valid CAS Registry Number.

2707-17-7Relevant academic research and scientific papers

NOVEL HYDRAZINO-CYCLOBUT-3-ENE-1, 2-DIONE DERIVATIVES AS CXCR2 ANTAGONISTS

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Page/Page column 35, (2010/09/03)

The present invention relates to novel hydrazino-cyclobut-3-ene-1,2-dione compounds of Formula (I) as selective CXCR2 antagonists, pharmaceutical compositions containing the novel compounds, as well as methods for treating or preventing chemokine mediated

Design, synthesis, and evaluation of novel 3-amino-4-hydrazine-cyclobut-3-ene-1,2-diones as potent and selective CXCR2 chemokine receptor antagonists

Liu, Shilan,Liu, Yinhui,Wang, Hongmei,Ding, YiLi,Wu, Hao,Dong, Jingchao,Wong, Angela,Chen, Shu-Hui,Li, Ge,Chan, Manuel,Sawyer, Nicole,Gervais, Francois G.,Henault, Martin,Kargman, Stacia,Bedard, Leanne L.,Han, Yongxin,Friesen, Rick,Lobell, Robert B.,Stout, David M.

scheme or table, p. 5741 - 5745 (2010/04/30)

We describe herein a novel series of 3-amino-4-hydrazine-cyclobut-3-ene-1,2-diones as potent and selective inhibitors against the CXCR2 chemokine receptor and IL-8-mediated chemotaxis of a CXCR2-expressing cell line. Furthermore, these alkyl-hydrazine series inhibitors such as 5b demonstrated acceptable metabolic stability when incubated in human and rat microsomes.

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