210751-69-2Relevant academic research and scientific papers
A facile route to functionalized cyclopenta[b]thiophenones based on the structure of the selective COX-2 inhibitor Flosulide
Binder, Dieter,Pyerin, Michael,Steindl, Roman,Weisgram, Martin
, p. 887 - 896 (2007/10/03)
The synthesis of three thiophene analogues of Flosulide - a potent and selective inhibitor of cyclooxygenase subtype 2 (COX-2) - is described. Utilizing combined Friedel-Crafts acylation and alkylation of 2-chlorothiophene, simplified procedures were deve
