210754-59-9 Usage
Uses
Used in Pharmaceutical Industry:
N-FMOC-(2S,3S)-3-AMINO-2-HYDROXY-4-PHENYL-BUTYRIC ACID is used as a building block for the synthesis of complex peptides and pharmaceuticals, leveraging its FMOC protecting group to facilitate solid-phase peptide synthesis. This allows for the development of new drugs with specific therapeutic targets and improved pharmacological properties.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, N-FMOC-(2S,3S)-3-AMINO-2-HYDROXY-4-PHENYL-BUTYRIC ACID is utilized as a key component in the design and synthesis of novel peptide-based therapeutic agents. Its unique stereochemistry and functional groups enable the exploration of new peptide sequences with potential applications in treating various diseases and conditions.
Used in Peptide Drug Development:
N-FMOC-(2S,3S)-3-AMINO-2-HYDROXY-4-PHENYL-BUTYRIC ACID is employed as a crucial intermediate in the development of peptide drugs, taking advantage of its ability to form stable peptide bonds and its compatibility with solid-phase synthesis techniques. This contributes to the advancement of peptide-based medications with enhanced stability, bioavailability, and efficacy.
Used in Biochemistry and Molecular Biology:
N-FMOC-(2S,3S)-3-AMINO-2-HYDROXY-4-PHENYL-BUTYRIC ACID also serves as a valuable tool in biochemical and molecular biology research, where it can be used to study the interactions of peptides with biological targets, such as enzymes, receptors, and other macromolecules. Its specific configuration and functional groups allow for the investigation of structure-activity relationships and the elucidation of peptide binding mechanisms.
Check Digit Verification of cas no
The CAS Registry Mumber 210754-59-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,0,7,5 and 4 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 210754-59:
(8*2)+(7*1)+(6*0)+(5*7)+(4*5)+(3*4)+(2*5)+(1*9)=109
109 % 10 = 9
So 210754-59-9 is a valid CAS Registry Number.
210754-59-9Relevant academic research and scientific papers
Evaluation of transition-state mimics in a superior BACE1 cleavage sequence as peptide-mimetic BACE1 inhibitors
Hattori, Yasunao,Kobayashi, Kazuya,Deguchi, Ayaka,Nohara, Yukie,Akiyama, Tomomi,Teruya, Kenta,Sanjoh, Akira,Nakagawa, Atsushi,Yamashita, Eiki,Akaji, Kenichi
, p. 5626 - 5640 (2015/11/11)
A superior substrate sequence for BACE1 containing transition-state mimics at the scissile site was evaluated as a protease inhibitor. Hydroxymethylcarbonyl (HMC) and hydroxyethylamine (HEA) isosteres were selected as the transition state mimics, and inco
PEPTIDE DERIVATIVES HAVING BETA-SECRETASE INHIBITORY ACTIVITY
-
, (2008/06/13)
Provided are excellent β-secretase inhibitors, that is, compounds represented by the general formula (1) or prodrugs thereof: wherein A is amino or protected amino; B1 and B2 are each a single bond, alkylene of 1 to 3 carbon atoms, or the like; D is a single bond, -NHCO, or the like; E is -COOH, tetrazole ring, or the like; n is an integer of 1 to 3; m is an integer of 1 to 3; G is hydroxyl, a group represented by the general formula (2), or the like: ???in which Z is -NH, -Asp-Ala-NH-, -Asp-Ala-, -Asp-NH-, or the like; L is a 5-to 10-membered ring optionally containing a heteroatom and/or unsaturated bond; X is -COOH, tetrazole ring, or the like; Y is hydrogen, -COOH, or the like; and k is an integer of 1 to 4; and R1, R2, and R3 are each alkyl of 1 to 6 carbon atoms, or the like.
