(2S,3S)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-hydroxy-4-phenylbutanoic acid

Base Information

• Chemical Name: (2S,3S)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-hydroxy-4-phenylbutanoic acid
• CAS No.: 210754-59-9
• Molecular Formula: C25H23 N O5
• Molecular Weight: 417.461
• DSSTox Substance ID: DTXSID20373283
• Wikidata: Q72478484
• Mol file: 210754-59-9.mol

Synonyms:210754-59-9;N-Fmoc-(2S,3S)-3-amino-2-hydroxy-4-phenyl-butyric acid;(2S,3S)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-hydroxy-4-phenylbutanoic acid;Fmoc-(2S,3S)-AHPA;(2S,3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-2-hydroxy-4-phenylbutanoic acid;(2S,3S)-3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-hydroxy-4-phenylbutanoic acid;Fmoc-(2S,3S)-3-amino-2-hydroxy-4-phenylbutyric acid;SCHEMBL14578757;DTXSID20373283;MFCD00467714;AKOS015949871;CS-0336469;E70545;n-fmoc-(2s,3s)-3-amino-2-hydroxy-4-phenylbutyric acid

Chemical Property of (2S,3S)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-hydroxy-4-phenylbutanoic acid

Chemical Property:

• PSA: 95.86000
• Density: 1.313±0.06 g/cm3 (20 ºC 760 Torr)
• LogP: 3.97280
• Storage Temp.: Store at 0°C
• XLogP3: 4
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 8
• Exact Mass: 417.15762283
• Heavy Atom Count: 31
• Complexity: 597

Purity/Quality:

99.0% ^*data from raw suppliers

N-Fmoc-(2s,3s)-3-amino-2-hydroxy-4-phenyl-butyricacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CC(C(C(=O)O)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24
• Isomeric SMILES: C1=CC=C(C=C1)C[C@@H]([C@@H](C(=O)O)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24

Technology Process of (2S,3S)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-hydroxy-4-phenylbutanoic acid

There total 4 articles about (2S,3S)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-hydroxy-4-phenylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Fmoc-phenylalanine ketoacid (1137148-17-4) → (3S)-3-([{(9H-fluoren-9-yl)methoxy}carbonyl]amino)-2-hydroxy-4-phenylbutanoic acid (210754-59-9,1391586-46-1) + (3S)-3-([{(9H-fluoren-9-yl)methoxy}carbonyl]amino)-2-hydroxy-4-phenylbutanoic acid (1391586-46-1)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; for 1.5h;

DOI:10.1016/j.bmc.2015.07.023

Reference yield:

C30H28N2O3S → (3S)-3-([{(9H-fluoren-9-yl)methoxy}carbonyl]amino)-2-hydroxy-4-phenylbutanoic acid (210754-59-9,1391586-46-1) + (3S)-3-([{(9H-fluoren-9-yl)methoxy}carbonyl]amino)-2-hydroxy-4-phenylbutanoic acid (1391586-46-1)

Guidance literature:

Multi-step reaction with 2 steps

1: Oxone / N,N-dimethyl-formamide; water / 0.5 h / 20 °C

2: sodium tetrahydroborate / methanol / 1.5 h / 0 - 20 °C

With Oxone; sodium tetrahydroborate; In methanol; water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2015.07.023

Reference yield:

N-Fmoc L-Phe (35661-40-6) → (3S)-3-([{(9H-fluoren-9-yl)methoxy}carbonyl]amino)-2-hydroxy-4-phenylbutanoic acid (210754-59-9,1391586-46-1) + (3S)-3-([{(9H-fluoren-9-yl)methoxy}carbonyl]amino)-2-hydroxy-4-phenylbutanoic acid (1391586-46-1)

Guidance literature:

Multi-step reaction with 3 steps

1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 14 h / 0 - 20 °C

2: Oxone / N,N-dimethyl-formamide; water / 0.5 h / 20 °C

3: sodium tetrahydroborate / methanol / 1.5 h / 0 - 20 °C

With Oxone; sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In methanol; water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2015.07.023

upstream raw materials:

Fmoc-phenylalanine ketoacid

N-Fmoc L-Phe

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 210754-59-9 N-FMOC-(2S,3S)-3-AMINO-2-HYDROXY-4-PHENYL-BUTYRIC ACID

Send

Send

Metric Ton KG G Pound L ML

Send

Send