210755-45-6 Usage
Uses
Used in Pharmaceutical Industry:
CP 471,474 is used as a broad-spectrum inhibitor of matrix metalloproteinases for attenuating early left ventricular dilation after experimental myocardial infarction in mice. It has been shown to reduce left ventricular enlargement and decrease the incidence of cardiac rupture when administered at specific doses.
Used in Respiratory Disease Treatment:
CP 471,474 is used as an inhibitor to reduce cigarette smoke-induced lung inflammation and the progression of emphysema in guinea pig models. Its ability to inhibit MMPs may provide therapeutic benefits in treating respiratory diseases associated with inflammation and tissue damage.
Used in Cardiovascular Disease Treatment:
In the pharmaceutical industry, CP 471,474 is used as a therapeutic agent for cardiovascular diseases, particularly myocardial infarction. Its inhibitory effects on MMPs help in reducing left ventricular dilation and cardiac rupture risks, offering potential benefits in the treatment and management of heart conditions.
Biochem/physiol Actions
CP-471474 is a broad spectrum inhibitor of matrix metalloproteinases. CP-471474 has a low nM IC50 efficacy for MMP-2, MMP-3, MMP-9, and MMP-13. CP-471474 has low potency against MMP-1 (IC50 > 1 uM). CP-471474 prevents left ventricular remodeling after experimental myocardial infarction in mice. CP-471474 also inhibits cigarette smoke-induced lung inflammation and the progression of emphysema in guinea pig models.
Check Digit Verification of cas no
The CAS Registry Mumber 210755-45-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,0,7,5 and 5 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 210755-45:
(8*2)+(7*1)+(6*0)+(5*7)+(4*5)+(3*5)+(2*4)+(1*5)=106
106 % 10 = 6
So 210755-45-6 is a valid CAS Registry Number.
210755-45-6Relevant academic research and scientific papers
Arylsulfonylamino hydroxamic acid derivatives
-
, (2008/06/13)
A compound of the formula wherein R1, R2and Q are as defined above, useful in the treatment of a condition selected from the group consisting of arthritis, cancer, tissue ulceration, macular degeneration, restenosis, periodontal dise
