210755-75-2Relevant academic research and scientific papers
Synthesis of a C-disaccharide glycosyl donor as a key building block for the preparation of new biologically active heparin pentasaccharide mimetics
Helmboldt, Arnim,Mallet, Jean-Maurice,Petitou, Maurice,Sinay, Pierre
, p. 1057 - 1068 (2007/10/03)
The synthesis of the C-disaccharide imidate 34, a key synthon for the synthesis of heparin pentasaccharide mimetics, is described.The C-interglycosidic bond was established through 9-endo-trig radical cyclization from two tethered monosaccharides.It was followed by conversion of the reducing end glucose unit into the required glucuronic acid derivative. - Keywords: heparin; silicon tether; radical cyclization; C-disaccharide; carbohydrate mimetics
