210834-68-7

Upstream product

• 210834-63-2 (1S,3aR,7aR)-3a-Hydroxy-7a-methyl-4-[(R)-2-(4,6,7,8-tetrahydro-benzo[1,3]dioxin-8a-yl)-ethyl]-5-trimethylsilanyloxy-2,3,3a,6,7,7a-hexahydro-1H-indene-1-carbonitrile 
• 210834-61-0 (1S,2R)-2-((R)-4-Benzenesulfonyl-3-oxo-6-4,6,7,8-tetrahydro-benzo[1,3]dioxin-8a-yl-hexyl)-2-methyl-3-oxo-cyclopentanecarbonitrile 
• 1026450-31-6 (1S,3aS,4S,7aR)-7a-Methyl-5-oxo-6-phenylsulfanyl-4-[(R)-2-(4,6,7,8-tetrahydro-benzo[1,3]dioxin-8a-yl)-ethyl]-3a-trimethylsilanyloxy-octahydro-indene-1-carbonitrile 
• 210834-65-4 (1S,3aS,4S,7aR)-7a-Methyl-5-oxo-4-[(R)-2-(4,6,7,8-tetrahydro-benzo[1,3]dioxin-8a-yl)-ethyl]-3a-trimethylsilanyloxy-octahydro-indene-1-carbonitrile 
• 210834-57-4 3-((1R,2S)-2-Cyano-1-methyl-5-oxo-cyclopentyl)-propionic acid methyl ester 
• 210834-67-6 Trifluoro-methanesulfonic acid (1S,3aS,4S,7aR)-1-cyano-7a-methyl-6-phenylsulfanyl-4-[(R)-2-(4,6,7,8-tetrahydro-benzo[1,3]dioxin-8a-yl)-ethyl]-3a-trimethylsilanyloxy-2,3,3a,4,7,7a-hexahydro-1H-inden-5-yl ester 
• 210758-61-5 (1S,3aS,4S,7aR)-3a-Hydroxy-7a-methyl-5-oxo-4-[(R)-2-(4,6,7,8-tetrahydro-benzo[1,3]dioxin-8a-yl)-ethyl]-octahydro-indene-1-carbonitrile 
• 210834-60-9 (R)-8a-(3-Benzenesulfonyl-propyl)-6,7,8,8a-tetrahydro-4H-benzo[1,3]dioxine 
• 182209-18-3 (1S,7aR)-7a-Methyl-5-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-1-carbonitrile 
• 181771-83-5 (R)-8a-(2-Iodo-ethyl)-6,7,8,8a-tetrahydro-4H-benzo[1,3]dioxine 

Relevant academic research and scientific papers

Intramolecular Heck cyclization of α-sulfenyl enol triflates. Asymmetric synthesis of a pentacyclic cardenolide precursor having functionality at C-11

A concise route to the core of complex cardenolides is described. The sequence features use of a sulfone to join enantioenriched A and D ring fragments and also control intramolecular aldolization to generate ring C and an intramolecular Heck cyclization of an α-sulfenyl enol triflate to form the steroid skeleton.