210835-69-1Relevant academic research and scientific papers
Synthesis of tripeptides containing α,α-diphenylglycine by the modified Ugi reaction
Yamada, Takashi,Omote, Yuichiro,Yamanaka, Yoshinori,Miyazawa, Toshifumi,Kuwata, Shigeru
, p. 991 - 998 (2007/10/03)
The modified Ugi reaction has been developed to synthesize tripeptides containing α,α-diphenylglycine (Dph) together with bulky amino acids. By the use of diphenylmethanimine, N-benzyloxycarbonyl (Z) amino acids and isocyanides derived from amino acids, very crowded tripeptides such as Z- Aib-Dph-Aib-OMe, Z-Ac6c-Dph-Aib-OMe, Z-Dph-Dph-Dph-OMe, etc. have been synthesized.
