183734-04-5Relevant articles and documents
Synthesis of tripeptides containing α,α-diphenylglycine by the modified Ugi reaction
Yamada, Takashi,Omote, Yuichiro,Yamanaka, Yoshinori,Miyazawa, Toshifumi,Kuwata, Shigeru
, p. 991 - 998 (2007/10/03)
The modified Ugi reaction has been developed to synthesize tripeptides containing α,α-diphenylglycine (Dph) together with bulky amino acids. By the use of diphenylmethanimine, N-benzyloxycarbonyl (Z) amino acids and isocyanides derived from amino acids, very crowded tripeptides such as Z- Aib-Dph-Aib-OMe, Z-Ac6c-Dph-Aib-OMe, Z-Dph-Dph-Dph-OMe, etc. have been synthesized.
A novel modification of the Ritter reaction using trimethylsilyl cyanide
Chen,Goel,Kesten,Knobelsdorf
, p. 8129 - 8132 (2007/10/03)
A new modification of the Ritter reaction using trimethylsilyl cyanide (Me3SiCN) is described, which converts alcohols to their corresponding formamides in high yields using a convenient procedure. The reaction conditions and mechanism are discussed. In some cases, new formamides are synthesized which cannot be prepared by the classical Ritter reaction.