21084-55-9

Usage

Uses

Used in Pharmaceutical Industry:
1-(Pyridin-4-yl)-pyrrolidin-2,5-dione is used as an intermediate in the synthesis of N-(4-Pyridyl)maleimide (P991865) for its antiamnesic and cognition-enhancing effects. This application is particularly relevant in the development of treatments for cognitive disorders and memory impairments.
Used in the Synthesis of 4-Aminopyridine Derivatives:
1-(Pyridin-4-yl)-pyrrolidin-2,5-dione is used as a key component in the production of 4-aminopyridine derivatives, which have demonstrated potential benefits in enhancing cognitive function and memory. These derivatives are being investigated for their use in treating various neurological conditions and improving overall brain health.

Upstream product

• 504-24-5 4-aminopyridine 
• 108-30-5 succinic acid anhydride 
• 77487-27-5 1-(2',6'-Dimethyl-4'-oxo-4H,4'H-[1,1']bipyridinyl-4-yl)-pyrrolidine-2,5-dione 

Relevant academic research and scientific papers

Design, synthesis and evaluation of some new 4-aminopyridine derivatives in learning and memory

Some new anilide and imide derivatives of 4-aminopyridine (4AP) were synthesized and evaluated against antiamnesic, cognition enhancing and anticholinesterase activity through their respective in vitro and in vivo models. These newly synthesized derivatives have illustrated an enhanced cognition effect on elevated plus maze model and also demonstrated a significant reversal in scopolamine-induced amnesia in same model. The IC50 value of synthesized compounds showed maximum activity of 4APMb compared to standard drug donepezil and other derivatives, whereas its enzyme kinetic study revealed a non-competitive inhibition of acetycholinesterase (AChE) and a competetive inhibition of butyrylcholinesterase (BChE). Significant inhibitions in AChE activity by all the synthesized compounds were found in specific brain regions that is prefrontal cortex, hippocampus and hypothalamus. The docking study confirmed their consensual interaction with AChE, showed an affinity and binding with the key peripheral anionic site residues Trp-286, Tyr-124 and Tyr-341 of AChE.

N-Quinazolinylpiperidinyl-lactams

N-[1-(4-amino-2-quinazolinyl)-3- or 4-piperidinyl]-lactams, e.g., those of the formula STR1 and salts thereof are antihypertensive agents.

Synthetic Applications of N-N Linked Heterocycles. Part 9. Preparation of α-(4-Pyridyl)nitroalkanes and N-(4-Pyridyl)azoles by Regiospecific Attack of Nitroalkyl and Azolyl Anions on N-(2,6-Dimethyl-4-oxopyridin-1-yl)pyridinium Salts

Sodium salts of nitroalkanes and of azoles react with N-(2,6-dimethyl-4-oxopyridin-1-yl)pyridinium salts (1) - (3) to give regiospecifically 1,4-dihydropyridines (12) - (14), (15), and (16) in high yields.Photolysis of the dihydropyridines gives α-(4-pyri