21084-66-2

Upstream product

• 103-72-0 phenyl isothiocyanate 
• 136-64-1 terephthalohydrazide 
• 100-20-9 terephthaloyl chloride 
• 103-71-9 phenyl isocyanate 

Downstream Products

• 21084-70-8 5,5′-(1,4-phenylene)bis(4-phenyl-4H-1,2,4-triazole-3-thiol) 
• 21084-70-8 5,5'-(1,4-phenylene)bis(4-phenyl-3-mercapto-1,2,4-triazole) 
• 156525-85-8 5,5′-(1,4-phenylene)bis(N-phenyl-1,3,4-thiadiazol-2-amine) 

Relevant academic research and scientific papers

Synthesis and Antiproliferative and Antilipolytic Activities of a Series of 1,3- and 1,4-Bis[5-(R-sulfanyl)-1,2,4-triazol-3-yl)benzenes

Abstract: A series of 1,3 and 1,4-bis[5-(R-sulfanyl)-1,2,4-triazol-3-yl)benzene derivatives were synthesized by the reaction of isophthalic and terephthalic acid hydrazides with methyl and aryl isothiocyanates, followed by base-catalyzed cyclization and a

Synthesis and molecular docking of some new bis-thiadiazoles as anti-hypertensive α-blocking agents

Twelve bis-thiadiazole derivatives were synthesized in high yield via the reaction of 2,2′-terephthaloyl bis(N-phenylhydrazine carbothioamide) with a variety of hydrazonoyl chlorides in ethanol containing catalytic amounts of TEA. All the newly synthesized compounds were characterized by physical and chemical tools (FT-IR, 1H NMR, 13C NMR, and Mass spectrometry). Moreover, all the novel synthesized derivatives were screened for their antihypertensive α-blocking efficacy against to assess their pharmaceutical significance. The encouraging promising results obtained from antihypertensive α-blocking activity studies on the newly synthesized derivatives make the synthesis of a new series of these compounds and studying of their pharmaceutical importance an active area for more and more investigations. The molecular docking of the most active derivative 15 b against the human dopamine D3 receptor was performed by the Molecular Operating Environment (MOE 2014. 0901) program.

Synthesis of some novel bis-1,2,4-triazole and bis-1,3,4-thiadiazole derivatives from terephthaloyl and isophthaloyl chlorides

An efficient synthesis of novel bis-1,2,4-triazole and bis-1,3,4- thiadiazole derivatives starting from terephthaloyl and isophthaloyl chlorides is described. Terephthaloyl or isophthaloyl chloride was allowed to react with hydrazine hydrate in refluxing ethanol to give a corresponding bis-hydrazide derivative. Further reaction of these compounds with isothiocyanates gave bis-thiosemicarbazide derivatives, which then underwent cyclization to bis-1,3,4-thiadiazoles in the presence of sulfuric acid. The cyclization of these compounds in the presence of sodium hydroxide resulted in the formation of bis-1,2,4-triazole-3-thioles. The structure of these compounds was characterized by IR, NMR, and elemental analysis.

Synthesis, characterization and antimicrobial study of substituted bis-[1,2,4,5]-dithiadiazine and bis-[1,3,4]-thiadiazolidine derivatives

Series of compounds [4-(3-phenylimino-6-aryl/alkylimino-[1,2,4,5]- dithiadiazinane-4-carbonyl)-phenyl]-(3-phenylimino-6-aryl/alkylimino-[1,2,4,5] -thiadiazinan-4-yl)-methanones and [4-(2-phenylimino-5-aryl/alkylimino-[1,3,4]- thiadiazolidine-3-carbonyl)-phenyl]-(2-phenylimino-5-aryl/alkylimino-[1,3,4] -thiadiazolidin-3-yl)-methanones have been synthesized by the interaction of di-(N-aryl/alkyl thiocarbamido)terephthalamides with N-phenyl-S-chloro isothiocarbamoyl chloride and N-phenyl isocyanodichloride respectively. These compounds on acetylation afforded bis-acetyl derivatives. These compounds have been assayed for their antimicrobial activity against gram-positive as well as gram-negative microorganisms.

Synthesis, characterization and antimicrobial study of substituted bis-[1,3,4]-oxadiazole, bis-[1,3,4]-thiadiazole and bis-[1,2,4]-triazole derivatives

Series of compounds 1,4-bis-(2-aryl/alkyl-amino-[1,3,4]-oxadiazol-5-yl)- benzenes, 1,4-bis-(2-aryl/alkyl-amino-[1,3,4]-thiadiazol-5-yl)-benzenes and 1,4-bis-(3-mercapto-4-aryl/alkyl-[1,2,4]-triazol-5-yl)-benzenes have been synthesized by the oxidative cyclization of di-(N-aryl/alkyl thiocarbamido) terephthalamides using alkaline ethanolic solution of iodine containing potassium iodide, ortho-phosphoric acid and aqueous potassium hydroxide solution respectively. These compounds on acetylation afforded bis-acetyl derivatives, on benzoylation afforded bis-benzoyl derivatives and on reaction with ethyl iodide afforded bis-ethylmercapto derivatives respectively. These compounds have been assayed for their antimicrobial activity against gram-positive as well as gram-negative microorganisms.

Synthesis and biological activities of novel 1,4-bridged bis-1,2,4-triazoles, bis-1,3,4-thiadiazoles and bis-1,3,4-oxadiazoles

The terephthalic acid hydrazide (1) reacted with phenyl / benzyl isothiocyanate 2a,b to yield the corresponding bis-thiosemicarbazides 4a,b, via acid hydrolysis of the intermediate 3 whereas cyclization of 4 gave the bis-1,2,4-triazoles 5,6 and bis-1,3,4-