21084-70-8

Upstream product

• 21084-66-2 2,2'-terephthaloylbis(N-phenylhydrazine carbothioamide) 
• 103-72-0 phenyl isothiocyanate 
• 136-64-1 terephthalohydrazide 
• 100-20-9 terephthaloyl chloride 

Downstream Products

• 491874-97-6 1,4-bis[5-(methylsulfanyl)-4-phenyl-4H-1,2,4-triazol-3-yl]benzene 

Relevant academic research and scientific papers

Synthesis and Antiproliferative and Antilipolytic Activities of a Series of 1,3- and 1,4-Bis[5-(R-sulfanyl)-1,2,4-triazol-3-yl)benzenes

Abstract: A series of 1,3 and 1,4-bis[5-(R-sulfanyl)-1,2,4-triazol-3-yl)benzene derivatives were synthesized by the reaction of isophthalic and terephthalic acid hydrazides with methyl and aryl isothiocyanates, followed by base-catalyzed cyclization and a

New Bis-4H-1,2,4-triazoles and Their In Vitro Study as DNA Methylation Inhibitors

Abstract: Bis-1,2,4-triazoles with aryl and alkyl linkers were synthesized. In order to increase their hydrophilicity and potential biological activity, pharmacophore electron-deficient groups (carboxylic, carboxamide, nitrile) were introduced into the molecule. Functionalized compounds revealed a new type of biological activity such as inhibition of the level of methylation of tumor DNA.

Synthesis of some novel bis-1,2,4-triazole and bis-1,3,4-thiadiazole derivatives from terephthaloyl and isophthaloyl chlorides

An efficient synthesis of novel bis-1,2,4-triazole and bis-1,3,4- thiadiazole derivatives starting from terephthaloyl and isophthaloyl chlorides is described. Terephthaloyl or isophthaloyl chloride was allowed to react with hydrazine hydrate in refluxing ethanol to give a corresponding bis-hydrazide derivative. Further reaction of these compounds with isothiocyanates gave bis-thiosemicarbazide derivatives, which then underwent cyclization to bis-1,3,4-thiadiazoles in the presence of sulfuric acid. The cyclization of these compounds in the presence of sodium hydroxide resulted in the formation of bis-1,2,4-triazole-3-thioles. The structure of these compounds was characterized by IR, NMR, and elemental analysis.

Synthesis, characterization and antimicrobial study of substituted bis-[1,3,4]-oxadiazole, bis-[1,3,4]-thiadiazole and bis-[1,2,4]-triazole derivatives

Series of compounds 1,4-bis-(2-aryl/alkyl-amino-[1,3,4]-oxadiazol-5-yl)- benzenes, 1,4-bis-(2-aryl/alkyl-amino-[1,3,4]-thiadiazol-5-yl)-benzenes and 1,4-bis-(3-mercapto-4-aryl/alkyl-[1,2,4]-triazol-5-yl)-benzenes have been synthesized by the oxidative cyclization of di-(N-aryl/alkyl thiocarbamido) terephthalamides using alkaline ethanolic solution of iodine containing potassium iodide, ortho-phosphoric acid and aqueous potassium hydroxide solution respectively. These compounds on acetylation afforded bis-acetyl derivatives, on benzoylation afforded bis-benzoyl derivatives and on reaction with ethyl iodide afforded bis-ethylmercapto derivatives respectively. These compounds have been assayed for their antimicrobial activity against gram-positive as well as gram-negative microorganisms.

Synthesis and biological activities of novel 1,4-bridged bis-1,2,4-triazoles, bis-1,3,4-thiadiazoles and bis-1,3,4-oxadiazoles

The terephthalic acid hydrazide (1) reacted with phenyl / benzyl isothiocyanate 2a,b to yield the corresponding bis-thiosemicarbazides 4a,b, via acid hydrolysis of the intermediate 3 whereas cyclization of 4 gave the bis-1,2,4-triazoles 5,6 and bis-1,3,4-