21084-67-3

Upstream product

• 21084-62-8 1.1'-Isophthaloyl bis <4-phenyl-3-thio semicarbazide> 
• 99-63-8 benzene-1,3-dicarbonyl dichloride 
• 2760-98-7 isophthalic dihydrazide 
• 103-72-0 phenyl isothiocyanate 

Downstream Products

• 1375488-98-4 2(1,3)-benzena-1⁽⁴⁾,3⁽⁴⁾-diphenyl-4,8-dithia-6-oxo-(1,3)(3,5)-1,2,4-triazolacyclooctaphane 
• 1375488-95-1 1,3-bis[4-phenyl-5-carbethoxymethylmercapto-1,2,4-triazol-3-yl]benzene 

Relevant academic research and scientific papers

Synthesis and Antiproliferative and Antilipolytic Activities of a Series of 1,3- and 1,4-Bis[5-(R-sulfanyl)-1,2,4-triazol-3-yl)benzenes

Abstract: A series of 1,3 and 1,4-bis[5-(R-sulfanyl)-1,2,4-triazol-3-yl)benzene derivatives were synthesized by the reaction of isophthalic and terephthalic acid hydrazides with methyl and aryl isothiocyanates, followed by base-catalyzed cyclization and a

Synthesis of some novel bis-1,2,4-triazole and bis-1,3,4-thiadiazole derivatives from terephthaloyl and isophthaloyl chlorides

An efficient synthesis of novel bis-1,2,4-triazole and bis-1,3,4- thiadiazole derivatives starting from terephthaloyl and isophthaloyl chlorides is described. Terephthaloyl or isophthaloyl chloride was allowed to react with hydrazine hydrate in refluxing ethanol to give a corresponding bis-hydrazide derivative. Further reaction of these compounds with isothiocyanates gave bis-thiosemicarbazide derivatives, which then underwent cyclization to bis-1,3,4-thiadiazoles in the presence of sulfuric acid. The cyclization of these compounds in the presence of sodium hydroxide resulted in the formation of bis-1,2,4-triazole-3-thioles. The structure of these compounds was characterized by IR, NMR, and elemental analysis.