2109-99-1

Upstream product

• 50-00-0 formaldehyd 
• 5445-77-2 2-benzylpropionaldehyde 
• 2109-87-7 2-Benzyl-1-methoxy-propan-2-ol 
• 100-39-0 benzyl bromide 
• 1504-55-8 (E)-3-phenyl-2-methyl-2-propenol 
• 55114-30-2 2-benzyl-2-methylmalonic acid diethyl ester 
• 607-81-8 diethyl 2-benzylmalonate 

Downstream Products

• 1160168-19-3 methyl 2,5-dimethyl-t-5-benzyl-1,3-dioxane-r-2-carboxylate 
• 1160168-18-2 methyl 2,5-dimethyl-c-5-benzyl-1,3-dioxane-r-2-carboxylate 
• 1660126-49-7 C₁₇H₃₀O₂Si 
• 1646541-03-8 2-benzyl-2-methyl-4-phenylbut-3-ynal 
• 1646540-25-1 2-benzyl-2-methyl-4-phenylbut-3-yn-1-ol 
• 1646540-21-7 C₂₄H₃₂OSi 
• 1646540-16-0 ((2-benzyl-2-methylbut-3-yn-1-yl)oxy)(tert-butyl)dimethylsilane 
• 1660126-46-4 C₁₇H₂₈O₂Si 
• 1264833-18-2 C₁₈H₂₀O₃ 
• 40548-52-5 2-benzyl-2-methyl-1,3-diiodopropane 
• 40548-55-8 2-Benzyl-2-methyl-1,3-dibrompropan 
• 40548-56-9 2-Benzyl-2-methyl-1,3-dichlorpropan 
• 30836-86-3 1-benzyl-1-methylcyclopropane 
• 594837-61-3 (2R,1'S)-2-hydroxymethyl-2-methyl-3-phenyl-N-(1'-phenylethyl)propionamide 

Relevant academic research and scientific papers

Esters of 2,5-multisubstituted-1,3-dioxane-2-carboxylic acid: their conformational analysis and selective hydrolysis

The carbomethoxy group at the C2 position of the 2,5-multisubstituted 1,3-dioxanes prefers the axial conformation rather than the equatorial one due to an anomeric effect. The trans isomers of the 5-monosubstituted compounds are more selectively hydrolyzed than the cis isomers. Based on the calculated results, hydrolysis to the trans isomers is attributed to the larger carbonyl charges of the trans than those of the cis isomers. The anomeric and homoanomeric effects will explain the axial preference of the carbomethoxy group and selective hydrolysis to the trans isomers. Furthermore, the calculated stability between the cis and trans isomers is in good agreement with the experimental results in the equilibrium state.

Synthesis and evaluation of α,α -disubstituted-3-mercaptopropanoic acids as inhibitors for carboxypeptidase A and implications with respect to enzyme inhibitor design

2-Ethyl-2-methyl-3-mercaptopropanoic acid (6) and 2-benzyl-2-methyl-3-mercaptopropanoic acid (7) were synthesized and evaluated as inhibitors for carboxypeptidase A (CPA), a prototypical zinc protease with the expectation that the binding affinities of these inhibitors would be augmented over those of 2-ethyl-3-methylsuccinic acid (2) and 2-benzyl-3-methylsuccinic acid (3), respectively, in light of the fact that the sulfhydryl group is a better zinc coordinating moiety than the carboxylate group. Contrary to the expectation, however, the inhibitory potency of 6 was not improved and that of 7 was rather attenuated by the replacement. A probable explanation for the unexpected results is offered.

Tethered α-boryl radical cyclizations of haloalkyl boronates

Boroalkyl radicals readily cyclize onto alkenyl and alkynyl traps tethered via a C-B-O linkage. Oxidative cleavage of the C-B bond of the temporary connection following cyclization affords 1,3-diols in good yields.

Synthesis of substituted cyclopropanes from 1,3-diols through the corresponding cyclic sulfates

The reaction of different cyclic sulfates 2 (easily prepared from the corresponding 1,3-diols 1 following the Sharpless methodology) with an excess of lithium powder and a catalytic amount of DTBB (5 mol %) leads to the corresponding substituted cyclopropanes 3 through a γ-elimination process, the sulfate ion acting as leaving group.