210918-52-8

Upstream product

• 4421-08-3 3-methoxy-4-hydroxybenzonitrile 
• 121-33-5 vanillin 
• 151719-92-5 3-methoxy-4-(3-chloropropoxy) benzaldehyde 
• 109-70-6 1.3-chlorobromopropane 

Downstream Products

• 1122661-13-5 4-(3-chloropropoxy)-5-methoxy-2-nitrobenzonitrile 
• 58113-30-7 4-(3-chloropropoxy)-3-methoxyacetophenone 
• 1048699-10-0 7-(3-chloropropoxy)-6-methoxy-4-(4-methylanilino)-1,2,3-benzotriazine 
• 1048699-01-9 7-(3-chloropropoxy)-6-methoxy-4-(4-trifluoromethylanilino)-1,2,3-benzotriazine 
• 1122661-16-8 2-amino-4-(3-chloropropoxy)-5-methoxybenzonitrile 
• 385784-72-5 2-amino-5-methoxy-4-(3-morpholin-4-ylpropoxy)benzonitrile 

Relevant academic research and scientific papers

4-heterocycle substituted quinazoline derivative and preparation method and application thereof

The invention discloses a 4-heterocycle substituted quinazoline derivative and a preparation method and application thereof. The compound has a structure expressed by a general formula (I): (please see the specification for the formula), in the formula, R1 and R2 are independently selected from hydrogen, a saturated or unsaturated five-membered heterocycle, or a saturated or unsaturated six-membered heterocycle, and n is an integer from 1 to 6; X is NH, O or S; and a heterocycle A is independently selected from pyridine or substituted pyridine, pyrimidine or substituted pyrimidine, pyrazol orsubstituted pyrazol, pyrazine or substituted pyrazine, thiazole or substituted thiazole, or benzothiazole or substituted benzothiazole. The compound or pharmaceutically formable salts thereof have aninhibitory effect on proliferation of tumor cells and can be used for preparing drugs for treatment of glioma, non-small cell lung cancer, breast cancer, colon cancer, stomach cancer, liver cancer andcervical cancer diseases.

Synthesis and biological evaluation of substituted 1,2,3-benzotriazines and pyrido[3,2-d]-1,2,3-triazines as inhibitors of vascular endothelial growth factor receptor-2

A novel series of substituted 1,2,3-benzotriazines and pyrido[3,2-d]-1,2,3- triazines were synthesized. The abilities of these compounds to inhibit the VEGFR-2 kinase activity and the proliferation of human microvascular endothelial cells (MVECs) were det

PROCESSES FOR THE PREPARATION OF 4'-[3-[4-(6-FLUORO-1,2-BENZISOXAZOL-3-YL)PIPERIDINO]PROPOXY]-3'-METHOXYACETOPHENONE AND INTERMEDIATES THEREOF

The present invention relates to processes for the preparation of 4'-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]propoxy]-3'-methoxyacetophenone and intermediates thereof. The present invention also provides a process for purifying 4'-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]propoxy]-3'-methoxyacetophenone to obtain the purity greater than about 98.0 area % to about 99.0 area % as measured by HPLC, preferably greater than about 99.0 area % to about 99.5 area%, more preferably greater about 99.5 area % to about 99.9 area %. individual impurities lower than about 0.15 area %, preferably lower than about 0.1 % and total impurities lower than about 0.5 area % by HPLC.

AROMATIC RING FUSED TRIAZINE DERIVATIVES AND USES THEREOF

The invention belongs to pharmaceutical field. The invention relates to the compounds according to Formula I, including their optically active forms, pharmaceutically acceptable salts or hydrates, and the pharmaceutical composition comprising thereof as a

THE AROMATIC RING TRIAZINE DERIVATIVES AND THE USES THEREOF

The invention belongs to pharmaceutical field. The invention relates to the compounds according to Formula I. including their optically active forms, pharmaceutically acceptable salts or hydrates, and the pharmaceutical composition comprising thereof as a

Design, synthesis, and antitumor activities of some novel substituted 1,2,3-benzotriazines

A series of novel substituted 1,2,3-benzotriazines based on the structures of vatalanib succinate (PTK787) and vandetanib (ZD6474) were designed and synthesized. The antiproliferative effects of these compounds were tested on microvascular endothelial cel