210962-35-9Relevant academic research and scientific papers
Rational design, synthesis, and structure-activity relationships of novel factor Xa inhibitors: (2-substituted-4-amidinophenyl)pyruvic and -propionic acids
Sagi, Kazuyuki,Nakagawa, Tadakiyo,Yamanashi, Masahiro,Makino, Shingo,Takahashi, Mitsuo,Takayanagi, Masaru,Takenaka, Kaoru,Suzuki, Nobuyasu,Oono, Seiji,Kataoka, Noriyasu,Ishikawa, Kohki,Shima, Sayaka,Fukuda, Yumiko,Kayahara, Takashi,Takehana, Shunji,Shima, Yoichiro,Tashiro, Kazumi,Yamamoto, Hiroshi,Yoshimoto, Ryota,Iwata, Seinosuke,Tsuji, Takashi,Sakurai, Kuniya,Shoji, Masataka
, p. 1845 - 1857 (2007/10/03)
An inhibitor of factor Xa (fXa), the m-substituted benzamidine AXC1578 (1a), was structurally modified with the aim of increasing its potency. In particular, pyruvic acid and propionic acid substituents were incorporated into the P1 benzamidine moiety to
BENZAMIDINE DERIVATIVES
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, (2008/06/13)
Benzamidine derivatives of the following formulae or analogs thereof, i. e., pharmaceutically acceptable salts thereof, are provided. These compounds or salts thereof have a blood-coagulation inhibiting effect based on an excellent effect of inhibiting the action of activated blood coagulation factor X, and they are useful as anticoagulants.
