210964-90-2Relevant academic research and scientific papers
Practical asymmetric approach to pyrrolidinones: Efficient synthesis of (+)-preussin and (-)-AHPPA
Kanazawa, Alice,Gillet, Sandra,Delair, Philippe,Greene, Andrew E.
, p. 4660 - 4663 (2007/10/03)
A novel, dichloroketene-chiral enol ether cycloaddition-based synthesis of enantiopure (+)-preussin and (-)-AHPPA has been realized. The efficient, highly stereoselective approach, which involves a Beckmann ring expansion reaction to access the key pyrrolidinone, proceeds in ca. 16% overall yield for each of the compounds.
