210964-93-5

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 210964-89-9 (+)-(4S,5S)-5-benzyl-4-[(1R)-1-(2,4,6-triisopropylphenyl)ethoxy]-2-pyrrolidinone 

Downstream Products

• 210964-90-2 (2S,3S,5R)-2-Benzyl-5-nonyl-3-[(R)-1-(2,4,6-triisopropyl-phenyl)-ethoxy]-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 210964-94-6 (+)-(2S,3S,5R)-2-benzyl-3-hydroxy-5-nonylpyrrolidine 
• 125356-66-3 (+)-preussin 

Relevant academic research and scientific papers

Practical asymmetric approach to pyrrolidinones: Efficient synthesis of (+)-preussin and (-)-AHPPA

A novel, dichloroketene-chiral enol ether cycloaddition-based synthesis of enantiopure (+)-preussin and (-)-AHPPA has been realized. The efficient, highly stereoselective approach, which involves a Beckmann ring expansion reaction to access the key pyrrolidinone, proceeds in ca. 16% overall yield for each of the compounds.