21103-30-0

Upstream product

• 6640-24-0 N-(m-chlorophenyl)piperazine 
• 75000-29-2 2-(2-(4-(3-chlorophenyl)piperazin-1-yl)ethyl)isoindoline-1,3-dione 

Downstream Products

• 206430-43-5 3-benzhydrylidene-1-{2-[4-(3-chloro-phenyl)-piperazin-1-yl]-ethyl}-pyrrolidine-2,5-dione 
• 724436-30-0 1-{2-[4-(3-chloro-phenyl)-piperazin-1-yl]-ethyl}-3-fluoren-9-ylidene-pyrrolidine-2,5-dione 
• 1146214-46-1 N-[2-{4-(3-chlorophenyl)-piperazin-1-yl}-ethyl]-pyrrolidine-2,5-dione 
• 1146214-48-3 N-[2-{4-(3-chlorophenyl)-piperazin-1-yl}-ethyl]-3-cyclohexyl-pyrrolidine-2,5-dione 
• 1221290-78-3 N-{2-[4-(3-chlorophenyl)piperazin-1-yl]ethyl}-2-quinoline carboxamide 
• 1221290-90-9 N-{2-[4-(3-chlorophenyl)piperazin-1-yl]ethyl}-3-quinoline carboxamide 
• 1221290-68-1 N-{2-[4-(3-chlorophenyl)piperazin-1-yl]ethyl}-2-quinoxaline carboxamide 
• 1262099-35-3 C₂₃H₂₆ClN₃O₂ 
• 1240266-51-6 C₂₅H₃₁ClN₄O*ClH 

Relevant academic research and scientific papers

Small-Molecule Inhibition of the UNC119–Cargo Interaction

N-Terminal myristoylation facilitates membrane binding and activity of proteins, in particular of Src family kinases, but the underlying mechanisms are only beginning to be understood. The chaperones UNC119A/B regulate the cellular distribution and signal

Chemical modifications on 4-arylpiperazine-ethyl carboxamide derivatives differentially modulate affinity for 5-HT1A, D4.2, and α2A receptors: Synthesis and in vitro radioligand binding studies

A series of substituted 4-aryl-piperazine-ethyl heteroarylcarboxamides were prepared and tested in in vitro radioligand binding studies. The presence of a quinoxaline has a favourable impact in terms of serotonin 5-HT1A versus dopamine D4.2 receptor selectivity. Compounds with a 3-CF3 group at the distal phenyl ring are the most effective in terms of affinity and selectivity for 5-HT1A versus D4.2 receptors. A 4-phenyl-1,2,3,6- tetrahydropyridine in place of the corresponding 4-phenyl-piperazine side chain is also favourable not only for the affinity for 5-HT1A and D4.2 receptors but also in some cases for α2A-adrenoceptors.

Synthesis and biological evaluation of oxazole derivatives as T-type calcium channel blockers

T-type calcium channel is one of therapeutic targets for the treatment of cardiovascular diseases and neuropathic pain. In this study, as a part of our ongoing efforts to develop potent T-type calcium channel blockers, we designed oxazole derivatives subs

Synthesis and biological evaluation of novel T-type Ca2+ channel blockers

A small molecule library of piperazinylalkylisoxazole derivatives containing about 600 compounds was designed, synthesized and evaluated for blocking effects on T-type Ca2+ channel. Several ligands were identified to possess high inhibitory activity against the T-type Ca 2+ channel. The compound 21 with trifluoromethyl substituents at C3-position of phenyl group (R1) and C2- position of phenyl group (R2) showed the highest inhibitory activity with IC50 value of 1.02μM, which is comparable to that of mibefradil.