21103-84-4

Basic information

• Product Name: 1-ethoxy-2-(2-hydroxyphenylhydrazono)butane-1,3-dione
• Synonyms: 1-ethoxy-2-(2-hydroxyphenylhydrazono)butane-1,3-dione
• CAS NO: 21103-84-4
• Molecular Weight: 250.254
• Mol File: 21103-84-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-ethoxy-2-(2-hydroxyphenylhydrazono)butane-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ethoxy-2-(2-hydroxyphenylhydrazono)butane-1,3-dione(21103-84-4)
• EPA Substance Registry System: 1-ethoxy-2-(2-hydroxyphenylhydrazono)butane-1,3-dione(21103-84-4)

Safety Data

• Hazardous Substances Data: 21103-84-4(Hazardous Substances Data)

Upstream product

• 141-97-9 ethyl acetoacetate 
• 95-55-6 2-amino-phenol 
• 19183-06-3 2-hydroxyphenyldiazonium chloride 
• 48103-02-2 2-Hydroxy-benzoldiazonium 

Downstream Products

• 1310823-77-8 1-(6-chlorobenzothiazol-2-yl)-3-methyl-4-(2-hydroxyphenylhydrazono)-2-pyrazolin-5-one 

Relevant articles and documents

Synthesis and antimicrobial activity of pyrazolinones and pyrazoles having benzothiazole moiety

A new class of 4-arylhydrazono-1-benzothiazolyl-3-methylpyrazolin-5-ones (3a-j) and 4-arylazo-1-benzothiazolyl-3,5-dimethylpyrazoles (4a-j) were designed as pharmacophore hybrids between pyrazolinone/pyrazole and benzothiazole moiety. The target molecules were efficiently synthesized by the cyclization of various oxobutyrates/pentane-2,4-dione derivatives with 6-chloro-2- hydrazinobenzothiazole in the presence of glacial acetic acid. The compounds were evaluated for their in vitro antimicrobial activity. Preliminary study of the structure-activity relationship revealed that electron-withdrawing groups in phenyl ring had a promising effect on the antimicrobial activity. Also, correlation study has been used to establish the relationships between the antibacterial activity and physicochemical parameter clogP. Springer Science+Business Media, LLC 2011.

THERMODYNAMICS OF COMPLEXATION OF LANTHANIDES BY 2-HYDROXYPHENYLHYDRAZOETHYLACETOACETATE (2-HPHEAA); 2-HYDROXYPHENYLHYDRAZOETHYLCYANOACETATE (2-HPHECA) AND 2-HYDROXYPHENYLHYDRAZOMALONONITRILE (2-HPHMN)

The thermodynamic parameters (ΔG, ΔH and ΔS) for the formation of 1:1 and 1:2 complexes between lanthanide cations and 2-HPHMN, 2-HPHECA and 2-HPHEAA were determined by potentiometric titrations in 75percent (v/v) methanol-water solutions of 0.10 M KNO3 ionic strength. It elucidated that the stepwise Gibbs energies of formation of metal complexes varied in the sequence, ΔG12 and the stepwise enthalpies, ΔH1>ΔH2, and thus, the stepwise entropies markedly decrease in the order, ΔS1>ΔS2. Both of the enthalpy and entropy of all complex systems are negative. The non-linear variation of the thermodynamic parameters as a function of ionic potential of lanthanide elements was discussed.