21103-84-4Relevant academic research and scientific papers
Synthesis and antimicrobial activity of pyrazolinones and pyrazoles having benzothiazole moiety
Amir, Mohd.,Javed, Sadique A.,Hassan, Mohd. Zaheen
experimental part, p. 1261 - 1270 (2012/07/31)
A new class of 4-arylhydrazono-1-benzothiazolyl-3-methylpyrazolin-5-ones (3a-j) and 4-arylazo-1-benzothiazolyl-3,5-dimethylpyrazoles (4a-j) were designed as pharmacophore hybrids between pyrazolinone/pyrazole and benzothiazole moiety. The target molecules were efficiently synthesized by the cyclization of various oxobutyrates/pentane-2,4-dione derivatives with 6-chloro-2- hydrazinobenzothiazole in the presence of glacial acetic acid. The compounds were evaluated for their in vitro antimicrobial activity. Preliminary study of the structure-activity relationship revealed that electron-withdrawing groups in phenyl ring had a promising effect on the antimicrobial activity. Also, correlation study has been used to establish the relationships between the antibacterial activity and physicochemical parameter clogP. Springer Science+Business Media, LLC 2011.
Orfho-hydroxyphenylhydrazo-β-diketones: Tautomery. Coordination ability, and catalytic activity of their copper(II) complexes toward oxidation of cyclohexane and benzylic alcohols
Kopylovich, Maximilian N.,Mahmudov, Kamran T.,Da Silva, M. Fatima C. Guedes,Figiel, Pawel J.,Karabach, Yauhen Yu.,Kuznetsov, Maxim L.,Luzyanin, Konstantin V.,Pombeiro, Armando J.L.
experimental part, p. 918 - 931 (2011/04/16)
New hydrazone o-HO-phenylhydrazo-β-diketones (OHADB),R1NHN=CR2R3 [R1 = HO-2-C6H4,R2 = R3 = COMe (H2L1,1),R2R3 = COCH2C(Me)2CH2CO (H2L2,2),R2 = COMe, R3 = COOEt (H2L4,4
THERMODYNAMICS OF COMPLEXATION OF LANTHANIDES BY 2-HYDROXYPHENYLHYDRAZOETHYLACETOACETATE (2-HPHEAA); 2-HYDROXYPHENYLHYDRAZOETHYLCYANOACETATE (2-HPHECA) AND 2-HYDROXYPHENYLHYDRAZOMALONONITRILE (2-HPHMN)
Ramadan, A. A. T.,El-Shetary, B. A.,Abdel-Moez, M. S.,Seleim, H. S.
, p. 25 - 34 (2007/10/02)
The thermodynamic parameters (ΔG, ΔH and ΔS) for the formation of 1:1 and 1:2 complexes between lanthanide cations and 2-HPHMN, 2-HPHECA and 2-HPHEAA were determined by potentiometric titrations in 75percent (v/v) methanol-water solutions of 0.10 M KNO3 ionic strength. It elucidated that the stepwise Gibbs energies of formation of metal complexes varied in the sequence, ΔG12 and the stepwise enthalpies, ΔH1>ΔH2, and thus, the stepwise entropies markedly decrease in the order, ΔS1>ΔS2. Both of the enthalpy and entropy of all complex systems are negative. The non-linear variation of the thermodynamic parameters as a function of ionic potential of lanthanide elements was discussed.
