21109-01-3

Basic information

• Product Name: 1H-Indole-2-carboxamide, 5-chloro-
• CAS NO: 21109-01-3
• Molecular Formula: C9H7ClN2O
• Molecular Weight: 194.62
• Mol File: 21109-01-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1H-Indole-2-carboxamide, 5-chloro-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-2-carboxamide, 5-chloro-(21109-01-3)
• EPA Substance Registry System: 1H-Indole-2-carboxamide, 5-chloro-(21109-01-3)

Safety Data

• Hazardous Substances Data: 21109-01-3(Hazardous Substances Data)

Usage

General Description

1H-Indole-2-carboxamide, 5-chloro- is a chemical compound with the molecular formula C9H8ClN3O. It is an indole derivative containing a chlorine atom at the 5-position. 1H-Indole-2-carboxamide, 5-chloro- has potential applications in pharmaceutical and chemical research, as it has been studied for its potential biological activities including antiviral, antifungal, and antibacterial properties. Additionally, it has been investigated for its potential use in the treatment of neurological disorders such as Alzheimer's disease and depression. 1H-Indole-2-carboxamide, 5-chloro- is a valuable tool for scientists and researchers studying the biological and therapeutic effects of indole derivatives.

Upstream product

• 4792-67-0 5-chloro-indole-2-carboxylic acid ethyl ester 
• 10517-21-2 5-chloro-1H-Indole-2-carboxylic acid 
• 64507-05-7 5-chloroindole-2-carbonyl chloride 

Downstream Products

• 148473-16-9 5-chloro-3-(phenylthio)-1H-indole-2-carboxamide 

Relevant articles and documents

Iodine/Manganese Catalyzed Sulfenylation of Indole via Dehydrogenative Oxidative Coupling in Anisole

This protocol describes an iodine/manganese catalytic system for dehydrogenative oxidative coupling reaction of indoles with thiols in anisole. Particularly, the dual roles of anisole have been first demonstrated as a solvent and as a promoter via the formation of an oxonium ion intermediate to accelerate the generation of products. A series of sulfenylindoles are readily constructed under aerobic mild reaction conditions. In addition, the achievement for preparing anticancer and anti-AIDS drugs testifies the practicability of this approach. The mechanism studies disclose probable alternative pathways and a single-electron transfer process are involved in this transformation. (Figure presented.).

Indole-2-carboxamidines as novel NR2B selective NMDA receptor antagonists

A novel series of indole-2-carboxamidine derivatives was prepared and identified as NR2B selective NMDA receptor antagonists. The influence of the substituents on the indole skeleton as well as the substitution of the benzyl moiety on the biological activ