21110-91-8

Upstream product

• 16252-88-3 5-nitro-2,1,3-benzothiadiazole 
• 99-56-9 4-Nitrophenylene-1,2-diamine 
• 108-24-7 acetic anhydride 
• 874-37-3 benzo[1,2,5]thiadiazol-5-ylamine 

Downstream Products

• 874-37-3 benzo[1,2,5]thiadiazol-5-ylamine 
• 30536-22-2 5-amino-4-nitrobenzo[1,2,5]thiadiazole 
• 1711-66-6 benzo[1,2,5]thiadiazole-4,5-diamine 
• 2518-38-9 2-Methyl-thiazolo-<4.5-g>-benz-2.1.3-thiodiazol 

Relevant academic research and scientific papers

Benzothiadiazole compound and preparation method and use thereof

The present invention relates to a benzothiadiazole compound represented by the following formula I, and a preparation method and use thereof, the benzothiadiazole compound has the biological activityof inhibiting protein-tyrosine-phosphatase SHP2, can be used as a tool compound to study the biological functional relevance of the protein-tyrosine-phosphatase SHP2 in a cell signal transduction process, and provides a new means for prevention and treatment of cancer and metabolic and immune diseases.

FRIES REACTION AND DAKIN REARRANGEMENT IN BENZO-2,1,3-THIADIAZOLES

The Fries rearrangement of 4- and 5-acetoxybenzo-2,1,3-thiadiazoles has given 4-hydroxy-7-acetyl- and 5-hydroxy-4-acetylbenzo-2,1,3-thiadiazoles, which on oxidation afford mixtures of 5-chloro-4,7-dioxo- and 5,6-dichloro-4,7-dioxobenzo-2,1,3-thiadiazole and of 6-chloro-4,5-dioxo- and 6,7-dichloro-4,5-dioxobenzo-2,1,3-thiadiazole.Reaction of 6,7-dichloro-4,5-dioxobenzo-2,1,3-thiadiazole with ortho-phenylenediamine gives 4,5-dichloro-2,1,3-thiadiazolophenazine.