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2112-22-3

2112-22-3

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2112-22-3 Usage

Chemical Properties

Brown Solid

Uses

Different sources of media describe the Uses of 2112-22-3 differently. You can refer to the following data:
1. Anagrelide intermediate.
2. 2,3-Dichloro-6-nitrobenzonitrile may be employed as a starting reagent for the synthesis of ethyl (2-amino-5,6-dichlorobenzyl)glycinate.
3. Anagrelide

General Description

2,3-Dichloro-6-nitrobenzonitrile can be synthesized from 4-nitro-1,2,3-trichlorobenzene. It is formed as an intermediate during the synthesis of anagrelide.

Check Digit Verification of cas no

The CAS Registry Mumber 2112-22-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,1,1 and 2 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 2112-22:
(6*2)+(5*1)+(4*1)+(3*2)+(2*2)+(1*2)=33
33 % 10 = 3
So 2112-22-3 is a valid CAS Registry Number.
InChI:InChI=1/C7H2Cl2N2O2/c8-5-1-2-6(11(12)13)4(3-10)7(5)9/h1-2H

2112-22-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,3-Dichloro-6-nitrobenzonitrile

1.2 Other means of identification

Product number -
Other names 2,3-dichlro-6-nitrobenzonitrile

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2112-22-3 SDS

2112-22-3Relevant articles and documents

METHOD FOR THE PRODUCTION OF ANAGRELIDE HYDROCHLORIDE

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Page/Page column 4-5, (2010/02/13)

Disclosed is a method for producing 6,7-dichloro-1,5-dihydroimidazo[2,1-b]quinazoline-2(3H)-on hydrochloride (anagrelide hydrochloride). Said method comprises the following steps: a) 2,3-dichlorobenzaldehyde is nitrated to obtain 2,3-dichloro-6-nitrobenzaldehyde; b) 2,3-dichloro-6-nitrobenzaldehyde is reacted with hydroxylamine HCl and acetic anhydride by applying heat so as to obtain 2,3-dichloro-6-nitrobenzonitrile; c) the nitro group of 2,3-dichloro-6-nitrobenzonitrile is reduced to obtain 2,3-dichloro-6-aminobenzonitrile; d) the nitrile group of 2,3-dichloro-6-aminobenzonitrile is reduced to obtain 2,3-dichloro-6-aminobenzylamine dihydrochloride; e) 2,3-dichloro-6-aminobenzylamine dihydrochloride is reacted with i) bromoacetic acid ethyl ester, CH3CN, and triethylamine; and ii) BrCN to obtain (2-amino-5,6-dichloro-4H-quinazoline-3-yl) acetic acid ethyl ester; f) (2-amino-5,6-dichloro-4H-quinazoline-3-yl) acetic acid ethyl ester is reacted in cycloalkylation conditions to obtain 6,7-dichloro-1,5-dihydroimidazo[2,1-b]quinazoline-2(3H)-on; and g) 6,7-dichloro-1,5-dihydroimidazo[2,1-b]quinazoline-2(3H)-on is reacted with HCl to obtain anagrelide hydrochloride.

A simple synthesis of 2,3-dichloro-6-nitrobenzonitrile

Trinka,Berecz,Reiter

, p. 679 - 680 (2007/10/03)

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