21120-91-2

Basic information

• Product Name: 1-Bromobenzocyclobutene
• Synonyms: 1-BROMOBENZOCYCLOBUTENE;1-BroMobenzocyclobutene;7-BroMobicyclo[4.2.0]octa-1,3,5,7-tetraene;1-BrBCB 1-Bromobenzocyclobutene;1-Bromobenzocyclobutene 95%
• CAS NO: 21120-91-2
• Molecular Formula: C₈H₇Br
• Molecular Weight: 181.03
• Product Categories: API intermediates;Alkenyl;Halogenated Hydrocarbons;Organic Building Blocks;Aluminium foil bag/Fluoride bottle or on your request
• Mol File: 21120-91-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 90 °C10.5 mm Hg(lit.)
• Flash Point: 205 °F
• Appearance: /
• Density: 1.45 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.168mmHg at 25°C
• Refractive Index: n20/D 1.59(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-Bromobenzocyclobutene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Bromobenzocyclobutene(21120-91-2)
• EPA Substance Registry System: 1-Bromobenzocyclobutene(21120-91-2)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 21120-91-2(Hazardous Substances Data)

Usage

Chemical Properties

Colorless to pale yellow liquid

Uses

1-Bromobenzocyclobutene may be used in the synthesis of following compounds:five-membered zirconacyclesbenzocyclobutenol and benzocyclobutenone2,3-dimethoxyprotoberberinium bromide, via reaction with 3,4-dihydro-6,7-dimethoxyisoquinoline

General Description

1-Bromobenzocyclobutene is a useful synthon. It has important applications in organometallic methodology. Reaction between cycloheptatriene, bromoform, potassium carbonate and 18-crown-6 at 140°C yields 1-bromobenzocyclobutene.

InChI:InChI=1/C8H7Br/c9-8-5-6-3-1-2-4-7(6)8/h1-4,8H,5H2

Upstream product

• 694-87-1 benzocyclobutene 
• 3469-03-2 1-acetoxycyclobutabenzene 
• 118-92-3 anthranilic acid 
• 6639-21-0 1,2-Dijod-benzocyclobutan 
• 75-25-2 Bromoform 
• 544-25-2 Cyclohepta-1,3,5-triene 
• 35447-99-5 1,2-dihydrobenzocyclobuten-1-ol 
• 593-60-2 Vinyl bromide 
• 1608-42-0 benzenedizolium-2-carboxylate 

Downstream Products

• 78329-06-3 1-iodobenzocyclobutene 
• 6809-91-2 1-cyanobenzocyclobutane 
• 733810-61-2 7-(2-methylphenyl)bicyclo[4.2.0]octa-1,3,5-triene 
• 35447-99-5 1,2-dihydrobenzocyclobuten-1-ol 
• 121625-11-4 2-(bicyclo[4.2.0]octa-1,3,5-trien-7-yloxy)ethan-1-ol 
• 21118-86-5 ethyl (acetylamino)(bicyclo[4.2.0]octa-1,3,5-trien-7-yl)cyanoacetate 
• 483995-11-5 [(η5-cyclopentadienyl)ZrCH3(1-benzocyclobutenyl)] 
• 52199-49-2 1-benzocyclobutenecarboxamide 
• 61599-85-7 bicyclo[4.2.0]octa-1,3,5-trien-7-amine 
• 35095-07-9 Methyl bicyclo<4.2.0>octa-1,3,5-triene-7-carboxylate 
• 163222-89-7 1,2-dihydrocyclobutabenzene-1-carboxylic acid 
• 661476-70-6 7-p-tolybicyclo(4.2.0)octa-1,3,5-triene 

Relevant articles and documents

Studies on the syntheses of heterocyclic compounds DXLV. An alternative synthesis of the protoberberine ring system

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DENDRITIC MOLECULAR INTRACELLULAR TRANSPORTERS AND METHODS OF MAKING AND USING SAME

In accordance with the purpose(s) of the invention, as embodied and broadly described herein, the invention, in one aspect, relates to compounds comprising the structure: and at least one guanidinium residue, wherein m is zero or a positive integer. Also disclosed are methods of preparing the disclosed compounds. Also disclosed are methods of intracellular delivery comprising administering the disclosed compounds and compositions to a subject. Also disclosed are pharmaceutical compositions comprising a therapeutically effective amount of one or more compounds or compositions of the invention and a pharmaceutically acceptable carrier. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

1-Bromobenzocyclobutene: A Convenient Entry into the Benzocyclobutene Ring System

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