2113-88-4

Basic information

• Product Name: 4-acetyl-5-hydroxy-2-(2-methylpropyl)-1,2-dihydro-3H-pyrrol-3-one
• CAS NO: 2113-88-4
• Molecular Formula: C₁₀H₁₅NO₃
• Molecular Weight: 197.231
• Mol File: 2113-88-4.mol

Chemical Properties

• Boiling Point: 327.4°C at 760 mmHg
• Flash Point: 151.8°C
• Density: 1.162g/cm³
• Vapor Pressure: 1.54E-05mmHg at 25°C
• Refractive Index: 1.511
• CAS DataBase Reference: 4-acetyl-5-hydroxy-2-(2-methylpropyl)-1,2-dihydro-3H-pyrrol-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-acetyl-5-hydroxy-2-(2-methylpropyl)-1,2-dihydro-3H-pyrrol-3-one(2113-88-4)
• EPA Substance Registry System: 4-acetyl-5-hydroxy-2-(2-methylpropyl)-1,2-dihydro-3H-pyrrol-3-one(2113-88-4)

Safety Data

• Hazardous Substances Data: 2113-88-4(Hazardous Substances Data)

Upstream product

• 62972-97-8 methyl 2-[N-(1,3-dioxobutyl)amino]-4-methylpentanoate 
• 6322-53-8 leucine methyl ester hydrochloride 
• 7517-19-3 methyl (L)-leucinate hydrochloride 
• 62972-97-8 Methyl N-acetoacetyl-L-leucinate 

Relevant articles and documents

3-hydrazido and 3-hydrazono derivatives of tenuazonic acid and their herbicide evaluation

With the aim of optimizing the structure of tenuazonic acid and improving the herbicidal activity, hydrazine moieties were introduced to the 3-position of pyrrolidine-2,4-dione scaffold of tenuazonic acid. 3-Hydrazido-pyrrolidine-2,4- dione compounds (4a, 4b, 4c, 4d, 4e) were prepared from corresponding carboxylates and hydrazines via a microwave-assisted amidation, whereas 3-hydrazono compounds (7a, 7b, 7c, 7d, 7e) were prepared from corresponding 3-acetyl pyrrolidine-2,4-dione. Both of the two structures also exhibited herbicidal activities, especially against the dicotyledonous species amaranth pigweed (Amaranthus retroflexus), but with different structure-activity relationship.

Tetramic Acid Chemistry. Part 1. Reinvestigation of Racemisation during the Synthesis of Tetramic Acids via Dieckmann Cyclisation

Epimerisation during the synthesis of tetramic acids by Dieckmann cyclisation of the corresponding chiral N-acyl-α-amino esters was investigated.In the case of the isoleucine derivative, the extent of epimerisation was directly evaluated by 1H NMR analysis of the 3-acylated tetramic acids (3a,b) and (5a).A chemical correlation was carried out in the case of the 5-benzyl derivative (8h).The moderate overall yield and the partial epimerisation at position C-5 limit the usefulness of this approach for tetramic acid preparation.