6322-53-8

Basic information

• Product Name: H-DL-LEU-OME HCL
• Synonyms: H-DL-LEU-OME HCL;DL-LEUCINE METHYL ESTER HYDROCHLORIDE;DL-LEUCINE-OME HCL;METHYL 2-AMINO-4-METHYLPENTANOATE HYDROCHLORIDE;TIMTEC-BB SBB003738;methyl DL-leucinate hydrochloride;H-DL-Leu-OMe;2-AMino-4-Methylpentanoic acid hydrochloride
• CAS NO: 6322-53-8
• Molecular Formula: C₇H₁₆NO₂*Cl
• Molecular Weight: 181.66
• EINECS: 228-681-1
• Mol File: 6322-53-8.mol
• Article Data: 36

Chemical Properties

• Boiling Point: 169.2 °C at 760 mmHg
• Flash Point: 42.7 °C
• Appearance: /
• Vapor Pressure: 1.56mmHg at 25°C
• Storage Temp.: 2-8°C
• CAS DataBase Reference: H-DL-LEU-OME HCL(CAS DataBase Reference)
• NIST Chemistry Reference: H-DL-LEU-OME HCL(6322-53-8)
• EPA Substance Registry System: H-DL-LEU-OME HCL(6322-53-8)

Safety Data

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37
• Hazardous Substances Data: 6322-53-8(Hazardous Substances Data)

Usage

Uses

H-DL-Leu-OMe HCl

InChI:InChI=1/C7H15NO2.ClH/c1-5(2)4-6(8)7(9)10-3;/h5-6H,4,8H2,1-3H3;1H/t6-;/m0./s1

Upstream product

• 55322-25-3 N-Benzyloxy-D-leucin-methylester 
• 328-38-1 (R)-leucine 
• 67-56-1 methanol 
• 328-39-2 LEUCINE 
• 112792-75-3 trans-dichlorobis(2-imino-3-methylpentane acid-methylester)palladium 
• 23032-21-5 D-leucine methyl ester 
• 17392-84-6 methyl (2S)-2-hydroxy-4-methylpentanoate 

Downstream Products

• 952-43-2 3,6-diisobutyl-2,5-piperazinedione 
• 71731-72-1 Formyl-phenylalanyl-leucin-methylester 
• 127852-93-1 N-cinnamoyl-D,L-leucine methyl ester 
• 87784-11-0 N-cinnamoyl-D-leucine methyl ester 
• 109924-89-2 racemic Ac-ΔPhe-Gly-Gly-Leu-OMe 
• 145512-65-8 (R)-α-methylbenzylcarbamoyl-D-leucine methyl ester 
• 28426-50-8 Z-Gly-D-LeuOMe 
• 99597-71-4 methyl-(N-Boc-L-phenylalanine)-D-leucinate 
• 68305-82-8 2-Benzenesulfonylamino-4-methyl-pentanoic acid methyl ester 
• 442900-68-7 Z-Trp-D-Leu-OMe 
• 684270-66-4 N-(2-nitrophenylsulfonyl)-D-leucine methyl ester 
• 66399-70-0 methyl 2-(benzylamino)-4-methylpentanoate 
• 1067976-37-7 (E)-2-(benzylidene-amino)-4-methyl-pentanoic acid methyl ester 

Relevant articles and documents

Photochemical Deracemization at sp3-Hybridized Carbon Centers via a Reversible Hydrogen Atom Transfer

A photochemical deracemization of 5-substituted 3-phenylimidazolidine-2,4-diones (hydantoins) is reported (27 examples, 69%-quant., 80–99% ee). The reaction is catalyzed by a chiral diarylketone which displays a two-point hydrogen bonding site. Mechanistic evidence (DFT calculations, radical clock experiments, H/D labeling) suggests the reaction to occur by selective hydrogen atom transfer (HAT). Upon hydrogen binding, one substrate enantiomer displays the hydrogen atom at the stereogenic center to the photoexcited catalyst allowing for a HAT from the substrate and eventually for its conversion into the product enantiomer. The product enantiomer is not processed by the catalyst and is thus enriched in the photostationary state.

N-1 BRANCHED ALKYL SUBSTITUTED IMIDAZO[4,5-C]QUINOLINE COMPOUNDS, COMPOSITIONS, AND METHODS

Imidazo[4,5-c]quinoline compounds having a substituent that is attached at the N-1 position by a branched group, single enantiomers of the compounds, pharmaceutical compositions containing the compounds, and methods of making the compounds are disclosed. Methods of use of the compounds as immune response modifiers, for inducing (or inhibiting) cytokine biosynthesis in humans and animals, and in the treatment of diseases including infectious and neoplastic diseases are also disclosed.

Cocrystallization of Chiral N7,N16-bis (S-1-Phenylethyl)-1,4,10,13-Tetraoxo-7,16-Diazacyclooctadecane-7,16-Dicarboxamide with Hydrochlorides of Methyl Ethers of Leucine and Valine Enantiomers

An attempt to co-crystallize N7,N16-bis(S-1-phenylethyl)-1,4,10,13-tetraoxo-7,16-diazacyclooctadecane-7,16-dicarboxamide (1) with hydrochlorides of methyl ethers (HCMEs) of L- and D-valine and also L- and D-leucine results in separate crystallization of diazacrown-ether 1 (or its monohydrate 1·H2O) and HCMEs of respective α-amino acids. Crystal structures of D-leucine 1·H2O (1) and HCME (2) compounds, which were not described previously, are solved by single crystal X-ray diffraction.