211316-29-9Relevant academic research and scientific papers
Inhibition of cathepsin G by 4H-3,1-benzoxazin-4-ones
Guetschow, Michael,Neumann, Uf
, p. 1935 - 1942 (1997)
A series of 4H-3,1-benzoxazin-4-ones is reported that inhibit the serine proteases human cathepsin G and bovine chymotrypsin. The synthesis and kinetic parameters of the alkaline hydrolysis is described. These compounds act as acyl-enzyme inhibitors of bo
Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: Peptidomimetic replacement of the P2 amino acid by 2-aminoaryl acids and other non-natural amino acids
Wang, Yan,Jia, Shaojuan,Tseng, Ben,Drewe, John,Cai, Sui Xiong
, p. 6178 - 6182 (2008/04/02)
As a continuation of our SAR studies of dipeptidyl aspartyl-fmk as caspase inhibitors, we explored the replacement of the P2 amino acid by a 2-aminoaryl acid or other non-natural amino acids. Several of these compounds, such as 6l and 6p, were
Studies on 2-benzyloxy-4H-3,1-benzoxazin-4-ones as serine protease inhibitors
Guetschow, Michael,Neumann, Ulf,Sieler, Joachim,Eger, Kurt
, p. 95 - 103 (2007/10/03)
The class of 3,1-benzoxazin-4-ones includes potent inhibitors of various serine proteases. Structural investigations on three 2-benyloxy-4H-3,1-benzoxazin-4-ones (1-3) are described with respect to their reactivity to alkaline hydrolysis. The 13/sup
