Inhibition of cathepsin G by 4H-3,1-benzoxazin-4-ones

Article abstract of DOI:10.1016/S0968-0896(97)00128-4

A series of 4H-3,1-benzoxazin-4-ones is reported that inhibit the serine proteases human cathepsin G and bovine chymotrypsin. The synthesis and kinetic parameters of the alkaline hydrolysis is described. These compounds act as acyl-enzyme inhibitors of bo