2114-83-2Relevant academic research and scientific papers
Iron-Enhanced Reactivity of Radicals Enables C-H Tertiary Alkylations for Construction of Functionalized Quaternary Carbons
Yamane, Yu,Yoshinaga, Kohei,Sumimoto, Michinori,Nishikata, Takashi
, p. 1757 - 1762 (2019)
Iron is one of the most attractive catalysts, especially for aromatic C-H functionalizations. However, stoichiometric amounts of oxidants and strong carbanions are required, and C-H tertiary alkylation, especially with electron-deficient alkyl groups, is unexplored. In this paper, we describe the development of iron-catalyzed selective C-H tertiary alkylations with heteroaromatics, in which an iron salt acts as a single-electron source and enhances the reactivity of a tertiary alkyl radical generated from α-bromocarbonyl compounds. Our established methodology was demonstrated in the efficient synthesis of various quaternary carbon atoms under very simple conditions.
Construction of vicinal quaternary carbons via Cu-catalyzed dearomative radical addition
Tsuchiya, Naoki,Nishikata, Takashi
supporting information, p. 718 - 721 (2019/07/08)
In this paper, we confirmed the dearomative addition of tertiary alkyl radicals onto BHT derivatives to form highly congested vicinal quaternary carbons to produce tert-alkylated styrenes in the presence of copper catalyst. Although there are three candid
