211449-24-0

Upstream product

• 118-93-4 o-hydroxyacetophenone 
• 88-10-8 N,N-diethylcarbamyl chloride 
• 108-95-2 phenol 
• 65009-00-9 O-phenyl N,N-diethylcarbamate 
• 108-24-7 acetic anhydride 
• 617-84-5 N-formyldiethylamine 
• 115237-66-6 O-(2-bromo)phenyl N,N-diethylcarbamate 
• 182489-46-9 Diethyl-carbamic acid 2-(1-diethylcarbamoyloxy-vinyl)-phenyl ester 
• 182490-46-6 O-(2-iodo-phenyl)-N,N-diethylcarbamate 

Downstream Products

• 69-72-7 salicylic acid 
• 1076-38-6 4-hydroxy[1]benzopyran-2-one 
• 519753-11-8 diethyl-carbamic acid 2-[3-bromo-1-(3,4-dimethoxy-phenyl)-8,9-dimethoxy-5,6-dihydro-pyrrolo[2,1-a]isoquinolin-2-yl]-phenyl ester 
• 519753-08-3 diethyl-carbamic acid 2-[1-(3,4-dimethoxy-phenyl)-8,9-dimethoxy-5,6-dihydro-pyrrolo[2,1-a]isoquinolin-2-yl]-phenyl ester 
• 741695-63-6 diethyl-carbamic acid 2-trimethylsilanyl-6-[2-(2-trimethylsilanyl-benzo[b]thiophen-3-yl)-vinyl]-phenyl ester 
• 741695-59-0 {3-[2-(2-diethylcarbamoyloxy-3-trimethylsilanyl-phenyl)-vinyl]-phenyl}-carbamic acid tert-butyl ester 
• 741695-61-4 Diethyl-carbamic acid 2-[(E)-2-(4-diethylsulfamoyl-phenyl)-vinyl]-6-trimethylsilanyl-phenyl ester 
• 741695-62-5 (E)-tert-butyl 4-(2-(diethylcarbamoyloxy)-3-(trimethylsilyl)styryl)benzoate 
• 741695-58-9 (E)-2-(2,4-dimethoxystyryl)-6-(trimethylsilyl)phenyl diethylcarbamate 
• 741695-49-8 (E)-2-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)vinyl)-6-(trimethylsilyl)phenyl diethylcarbamate 

Relevant academic research and scientific papers

Corrigendum to “Copper ferrite superparamagnetic nanoparticles as a heterogeneous catalyst for directed phenol/formamide coupling” [Tetrahedron Lett. 58 (2017) 3370–3373] (Tetrahedron Letters (2017) 58(34) (3370–3373), (S0040403917309048), (10.1016/j.tetl

The authors regret that some characterization images of the catalyst and some NMR data of the compounds in Table 2 were shown incorrectly in the Supplementary Data. The coupling reactions were therefore re-run using the reported procedure and isolation of

Copper ferrite superparamagnetic nanoparticles as a heterogeneous catalyst for directed phenol/formamide coupling

The copper ferrite-catalyzed, directed coupling of ortho-arylated phenols and dialkylformamides in the presence of a peroxide oxidant is described. Acyclic and cyclic amides were compatible with the reaction conditions. The copper ferrite catalyst is hete

Directed ortho-Metalation of O-Aryl N,N-Dialkylcarbamates: Methodology, Anionic ortho-Fries Rearrangement, and Lateral Metalation

The directed ortho-lithiation reactions of O-aryl N,N-dialkylcarbamates as well as O-1-naphthyl and O-2-naphthyl N,N-dialkylcarbamates with sec-butyllithium/tetramethylethylenediamine (sBuLi/TMEDA) followed by quenching with various electrophiles afford a range of polysubstituted aromatic compounds. If the solutions of the ortho-lithiated carbamates are warmed to room temperature without the addition of external electrophiles, salicylamide and 1- and 2-hydroxynaphthamide derivatives are formed through anionic ortho-Fries rearrangements. The relative stabilities and reactivities of different O-aryl N,N-dialkylcarbamates were investigated. The lateral metalation of 2-tolyl carbamates with lithium diisopropylamide (LDA) provides a route to benzo[b]furan-2(3H)-ones. Previously reported results are used in a comparison of seven O-based directed metalation groups in reactions with several electrophiles. The described methodology is useful for the preparation of 1,2,3-substituted aromatic compounds.

A nitrogen-doped porous carbon derived from copper phthalocyanines on/in ZIF-8 as an efficient photocatalyst for the degradation of dyes and the C[sbnd]H activation of formamides

A novel nitrogen doped carbon photocatalyst was successfully prepared from the carbonization of copper phthalocyanine (CuPc) on/in zeolitic imidazolate framework-8 (ZIF-8) hybrid. Carbonized catalysts derived from either ZIF-8 or CuPc exhibit poor activity towards the degradation of dyes (such as methyl orange (MO) and Rhodamine B (Rh B)), whereas carbonized CuPc complex supported on ZIF-8 exhibits extremely high performance. The weight ratios 1:2 and 1:8 of CuPc/ZIF-8 showed the high dye absorption activity, while the weight ratio 1:4 demonstrated the high photocatalytic activity in the presence of H2O2 as an oxidant. For the first time, the photocatalyst (Cu/N-PC) was used in C[sbnd]H activation of formamides in the presence of tert-butyl hydroperoxide (TBHP) as an oxidant. The reaction proceeded within 30 min, in the presence 0.02 mol% of Cu.

Nickel-catalyzed oxidative esterification of formamides with 1,3-dicarbonyl compounds under mild reaction conditions

Synthesis of enol carbamates was achieved via nickel-catalyzed oxidative coupling of formamides with 1,3-dicarbonyl compounds in the presence of tert-butyl hydroperoxide at 40?°C. Various derivatives of enol carbamates were synthesized by this method in good to excellent yields.

A Baker-Venkataraman retro-Claisen cascade delivers a novel alkyl migration process for the synthesis of amides

A simple extension of the carbamoyl Baker-Venkataraman rearrangement has been developed. If residual water in the reaction is not strictly excluded a Baker-Venkataraman retro-Claisen cascade takes place, giving amide products, in which an alkyl group apparently migrates between two functionalities of the substrate.

Synthesis of carbamates by direct C-H bond activation of formamides

Copper catalysed oxidative coupling reaction of formamides with β-keto esters and 2-carbonyl-substituted phenols successfully proceeded through direct C-H bond activation of formamides. The corresponding carbamates were formed with high stereoselectivity

Copper-catalyzed oxidative C-O coupling by direct C-H bond activation of formamides: Synthesis of enol carbamates and 2-carbonyl-substituted phenol carbamates

Formamide C-H bond activation has been achieved under oxidative conditions, using a copper catalyst and tert-butyl hydroperoxide (TBHP) as the external oxidant (see scheme). This oxidative coupling of a range of dialkyl formamides provides an easy, phosge

An ionic O → α- and β-vinyl carbamoyl translocation of 2-(O-carbamoyl) stilbenes

(Equation Presented) New anionic oxygen to α- and β-vinyl carbamoyl migration reactions, 17a and 26a-c → 18 and 30a-c, proceed under LDA-mediated conditions leading stereoselectively to highly substituted stilbenes bearing electron-donating and -withdrawing substituants. Compounds 17a and 26a-c are prepared by combination of efficient, directed ortho metalation, Sonogashira, and Suzuki-Miyaura cross-coupling procedures.

Further developments in the synthesis of lamellarin alkaloids via direct metal-halogen exchange

Direct metal-halogen exchange of 2-bromopyrrole carbonate derivatives with tert-butyllithium followed by the intramolecular lactonization of the resulting 2-pyrrole anion onto the carbonate provided the corresponding lamellarins in moderate to good yield.