211449-34-2

Basic information

• Product Name: N,N-diethyl-3-(2-hydroxyphenyl)-3-oxopropanamide
• Synonyms: N,N-diethyl-3-(2-hydroxyphenyl)-3-oxopropanamide
• CAS NO: 211449-34-2
• Molecular Weight: 235.283
• Mol File: 211449-34-2.mol

Chemical Properties

• CAS DataBase Reference: N,N-diethyl-3-(2-hydroxyphenyl)-3-oxopropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-diethyl-3-(2-hydroxyphenyl)-3-oxopropanamide(211449-34-2)
• EPA Substance Registry System: N,N-diethyl-3-(2-hydroxyphenyl)-3-oxopropanamide(211449-34-2)

Safety Data

• Hazardous Substances Data: 211449-34-2(Hazardous Substances Data)

Upstream product

• 31165-67-0 2'-benzyloxyacetophenone 
• 114250-21-4 methyl β-oxo-2-(phenylmethoxy)benzenepropanoate 
• 88-10-8 N,N-diethylcarbamyl chloride 
• 118-93-4 o-hydroxyacetophenone 
• 211449-24-0 diethylcarbamic acid 2-acetylphenyl ester 

Downstream Products

• 1076-38-6 4-hydroxy[1]benzopyran-2-one 

Relevant articles and documents

A Baker-Venkataraman retro-Claisen cascade delivers a novel alkyl migration process for the synthesis of amides

A simple extension of the carbamoyl Baker-Venkataraman rearrangement has been developed. If residual water in the reaction is not strictly excluded a Baker-Venkataraman retro-Claisen cascade takes place, giving amide products, in which an alkyl group apparently migrates between two functionalities of the substrate.

Synthesis of Spirofurooxindoles via Phenyliodine(III) Bis(trifluoroacetate) (PIFA)-Mediated Cascade Oxidative C?O and C?C Bond Formation

Upon treatment with solely a hypervalent iodine reagent of phenyliodine(III) bis(trifluoroacetate) (PIFA), 3-(2-hydroxyphenyl)-3-oxo-N-phenyl propanamides and a series of its derivatives were conveniently converted to a class of undocumented spirofurooxindoles under mild conditions. Control experiments provided evidence that this spirocyclization process encompassed a cascade oxidative reactions involving the formation of a C?O bond prior to that of C?C bond. (Figure presented.).

Directed ortho metalation-cross coupling links. Carbamoyl rendition of the Baker-Venkataraman rearrangement. Regiospecific route to substituted 4- hydroxycoumarins

A new carbamoyl Baker-Venkataraman rearrangement (4) which allows a general synthesis of substituted 4-hydroxycoumarins 8 in 43-82% overall yields is described; the intermediate arylketones 6 are efficiently prepared (59-91% yields) via a Directed ortho Metalation - Negishi cross coupling protocol from arylcarbamates 5 and the overall sequence provides a regiospecific anionic Friedel-Crafts complement for the construction of ortho-acyl phenols and coumarins.