21148-34-5Relevant academic research and scientific papers
Synthetic method of 1,3-substituted diphenylpropenes
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Paragraph 0053; 0055, (2017/07/23)
The present invention relates to a method for efficiently synthesizing a natural 1,3-substituted diphenylpropene compound having biological activity. The effective method synthesizes 1,3-substituted diphenylpropene compound 5 to 8 by using Friedel-Crafts
Synthetic cinnamylphenol derivatives as cancer chemopreventive agents
Ito, Chihiro,Itoigawa, Masataka,Kanematsu, Tetsufumi,Imamura, Yuuki,Tokuda, Harukuni,Nishino, Hoyoku,Furukawa, Hiroshi
, p. 902 - 909 (2008/03/27)
Several substituted cinnamylphenol (1,3-diphenylpropene) derivatives were synthesized and tested for their inhibitory activities against in vitro Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. The prenylated cinnamylphenols were found to show remarkably potent activity. Furthermore, prenylated cinnamylphenols (19 and 25) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. These results indicate that some prenylated cinnamylphenols might be valuable as potential cancer chemopreventive agents (anti-tumor promoters).
