2115-91-5 Usage
Description
Dendrobine is a sesquiterpenoid that has been found in D. nobile and has anticancer activity. It decreases viability of A549 cells when used at concentrations ranging from 2.5 to 15 μg/ml. It induces apoptosis in A549 cells when used at concentrations ranging from 1 to 10 μg/ml, as well as increases JNK phosphorylation and sensitizes A549 cells to cisplatin at 10 μg/ml. Dendrobine (50 mg/kg per day) reduces tumor growth in an A549 mouse xenograft model with an additive effect when used in combination with cisplatin.
Uses
Dendrobine is an alkaloid isolated from Dendrobium nobile and is an antagonist of β-alanine, taurine and of presynaptic inhibition in the frog spinal cord.
Check Digit Verification of cas no
The CAS Registry Mumber 2115-91-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,1,1 and 5 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 2115-91:
(6*2)+(5*1)+(4*1)+(3*5)+(2*9)+(1*1)=55
55 % 10 = 5
So 2115-91-5 is a valid CAS Registry Number.
InChI:InChI=1/C16H25NO2/c1-8(2)11-12-10-6-5-9-7-17(4)14(16(9,10)3)13(11)19-15(12)18/h8-14H,5-7H2,1-4H3/t9?,10?,11?,12-,13-,14?,16?/m1/s1
2115-91-5Relevant articles and documents
Kende et al.
, p. 4332 (1974)
Total synthesis of (-)-dendrobine
Kreis, Lukas M.,Carreira, Erick M.
, p. 3436 - 3439 (2012/06/30)
Cascading to alkaloids: An 18-step total synthesis of (-)-dendrobine is based on a reaction cascade with a key amine group (see scheme, Bn=benzyl). The amine is the initiator of the cascade and provides an efficient method for installing the stereocenters at C11 and C3. The overall transformation occurs stereoselectively only when the conversion is carried out without the isolation of intermediates. Copyright
A short synthesis of (-)-dendrobine
Cassayare, Jér?me,Zard, Samir Z.
, p. 6072 - 6073 (2007/10/03)
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