21151-43-9

Basic information

• Product Name: 6-[(1,3-thiazol-2-ylamino)methylidene]cyclohexa-2,4-dien-1-one
• CAS NO: 21151-43-9
• Molecular Formula: C₁₀H₈N₂OS
• Molecular Weight: 204.2483
• Mol File: 21151-43-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 371.5°C at 760 mmHg
• Flash Point: 178.5°C
• Density: 1.493g/cm³
• Vapor Pressure: 1.03E-05mmHg at 25°C
• Refractive Index: 1.808
• CAS DataBase Reference: 6-[(1,3-thiazol-2-ylamino)methylidene]cyclohexa-2,4-dien-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-[(1,3-thiazol-2-ylamino)methylidene]cyclohexa-2,4-dien-1-one(21151-43-9)
• EPA Substance Registry System: 6-[(1,3-thiazol-2-ylamino)methylidene]cyclohexa-2,4-dien-1-one(21151-43-9)

Safety Data

• Hazardous Substances Data: 21151-43-9(Hazardous Substances Data)

Upstream product

• 96-50-4 2-thiazolylamine 
• 90-02-8 salicylaldehyde 

Downstream Products

• 123391-13-9 {Re(P(C₆H₅)3)2(CO)2{(C₃H₂NS)NCHC₆H₄O}} 
• 96-50-4 2-thiazolylamine 
• 90-02-8 salicylaldehyde 
• 77203-85-1 2-[(2-Hydroxy-phenyl)-(thiazol-2-ylamino)-methyl]-cyclohexanone 
• 13159-88-1 2-(thiazol-2-ylamino-methyl)-phenol 

Relevant articles and documents

Hydrolysis of Imines: Kinetics and Mechanism of Spontaneous Acid-, Base-, and Metal Ion-induced Hydrolysis of N-Salicylidene-2-aminothiazole

The kinetics of hydrolysis of N-salicylidene-2-aminothiazole (HL) have been investigated in aqueous 5 percent MeOH (I=0.1 mol dm-3) in the presence and absence of CoII, NiII, CuII, and ZnII.The solven

Half-Sandwich Ruthenium Complexes with Schiff-Base Ligands: Syntheses, Characterization, and Catalytic Activities for the Reduction of Nitroarenes

A series of ruthenium(II) p-cymene complexes containing Schiff-base ligands [Ru(p-cymene)LCl] [HL = pyridyl-salicylimine (2a-2d); HL = thiazol-salicylimine (2e-2h); HL = benzothiazol-salicylimine (2i-2l)] have been synthesized and characterized. All Schiff-base ligands and half-sandwich ruthenium complexes were fully characterized by 1H and 13C NMR spectra, mass spectrometry, and infrared spectrometry. The molecular structures of ruthenium complexes 2b and 2k were further confirmed by single-crystal X-ray diffraction methods. Furthermore, these half-sandwich ruthenium complexes are active catalysts for the mild hydrogenation of nitroarenes to aromatic anilines in the presence of sodium tetrahydroborate reducing agent in water. The most efficient catalyst, 2b, was found be compatible with nitroarenes of various functional groups.

Theoretical calculations and experimental verification of the antibacterial potential of some monocyclic β-lactams containing two synergetic buried antibacterial pharmacophore sites

A new series of N-thiazole, 3-phenyl, 4-substituted phenyl azetidine-2-ones 4(a-h) have been synthesized in good yields starting from 2-aminothiazole 1. In the first step, then Schiff's bases 3(a-h) are prepared by the condensation of 2-aminothiazole 1 with different aryl aldehydes 2(a-h). Finally, monocyclic β-lactams, i.e. substituted azetidinones 4(a-h), were the products formed using three different methods by the dehydrative cyclocondensation of 3(a-h) with phenyl acetyl chloride in dioxane, phenyl acetic acid-thionyl chloride in dichloromethane and phenyl acetic acid-phosphorus oxychloride in dichloromethane in the presence of triethylamine. We found that latter method is the best as compared with the former two methods. The synthesized molecules 4(a-h) were screened for their antibacterial activity against four microorganisms: Staphylococcus aureus (Gram positive), Pseudomonas vulgaris (Gram positive), Pseudomonas aeruginosa (Gram negative), and Escherichia coli (Gram negative). Their antibacterial activities are reported, and on the basis of the screening data available, attempt is also made to elucidate the structure-activity relationship. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. Copyright Taylor & Francis Group, LLC.