211519-29-8

Upstream product

• 108-97-4 4-pyrone 
• 77504-78-0 <2-13C>ethyl acetoacetate 
• 67035-94-3 diethyl [2-¹³C]malonate 

Downstream Products

• 211519-35-6 Ethyl 4-methoxy[1-13C]benzoate 
• 70211-36-8 (4-13C)phenol 
• 211519-38-9 Diethyl 4-methoxy[1-13C]benzylphthalimidomalonate 
• 211519-34-5 3,4-Dihydroxy[1-13C]benzoic acid 
• 211519-37-8 4-Methoxy[1-13C]benzyl bromide 
• 211519-36-7 4-Methoxy[1-13C]benzyl alcohol 

Relevant academic research and scientific papers

The synthesis of [3,4,1′-13C3]genistein

A facile synthesis is described for [3,4,1′-13C 3]genistein for use as an internal standard in isoflavone analysis by mass spectrometric methods. Ethyl 4-hydroxy[1-13C]benzoate was first prepared from the reaction of dieth

SYNTHESIS OF 13C-LABELLED ESTROGEN ANALOGUES

There is provided a method of producing novel 13C-labelled estrogen analogues. The method preferably proceeds via an intermediate A or B or which is a mixture of (A) or (B): wherein a13C atom is located at one or more of positions 1, 2, 3 or 4 and wherein R is an optionally substituted alkane, alkene, alkyne or aryl group. Preferably R is -CH2Ph. An alternative preferred intermediate compound is 13C-resorcinol.

A convenient synthesis of 4-hydroxy[1-13c]benzoic acid and related ring-labelled phenolic compounds

4-Hydroxy[1-13C]benzoic acid (5) was synthesized starting from commercially available sodium [2-13C]acetate (1) by a 4-step sequence in an overall yield of 55-65%. Key step in this synthesis is the formation of the benzene ring by base-catalyzed condensation of diethyl [2-13C]malonate (3) with 4H-pyran-4-one. Acid 5 or its ethyl ester could be converted into 3,4- dihydroxy[1-13C]benzoic acid (9), D,L-[1'-13C]tyrosine (14) and 1,2,4- trihydroxy[4-13C]benzene (19) with high efficiency.