211519-38-9Relevant academic research and scientific papers
A convenient synthesis of 4-hydroxy[1-13c]benzoic acid and related ring-labelled phenolic compounds
Beyer, Jürgen,Lang-Fugmann, Susanne,Mühlbauer, Andrea,Steglich, Wolfgang
, p. 1047 - 1051 (2007/10/03)
4-Hydroxy[1-13C]benzoic acid (5) was synthesized starting from commercially available sodium [2-13C]acetate (1) by a 4-step sequence in an overall yield of 55-65%. Key step in this synthesis is the formation of the benzene ring by base-catalyzed condensation of diethyl [2-13C]malonate (3) with 4H-pyran-4-one. Acid 5 or its ethyl ester could be converted into 3,4- dihydroxy[1-13C]benzoic acid (9), D,L-[1'-13C]tyrosine (14) and 1,2,4- trihydroxy[4-13C]benzene (19) with high efficiency.
