2115706-15-3

Basic information

• Product Name: fexaramine-3
• CAS NO: 2115706-15-3
• Molecular Weight: 569.703
• Mol File: 2115706-15-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: fexaramine-3(CAS DataBase Reference)
• NIST Chemistry Reference: fexaramine-3(2115706-15-3)
• EPA Substance Registry System: fexaramine-3(2115706-15-3)

Safety Data

• Hazardous Substances Data: 2115706-15-3(Hazardous Substances Data)

Upstream product

• 1664-59-1 3-(3-nitrophenyl)acrylic acid methyl ester 
• 58186-45-1 methyl 3-aminocinnamate 
• 586-77-6 4-bromo-N,N-dimethylaniline 
• 74-89-5 methylamine 
• 171364-78-6 (4-(N,N-dimethylamino)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 585-79-5 m-nitrobromobenzene 
• 58186-45-1 3-(3-amino-phenyl)-acrylic acid methyl ester 
• 659-04-1 methyl 3-nitrocinnamate 
• 87700-60-5 6-bromonaphthalene-2-carbonyl chloride 

Relevant articles and documents

A novel intestinal-restricted FXR agonist

In this study, a new intestinal-restricted FXR agonist named fexaramine-3 (Fex-3) was developed and investigated both in vitro and in vivo. Fex-3 could selectively activate intestinal FXR and promote the expression of BSEP and SHP while suppressing CYP7A1 which is involved in bile acids syntheses better than the reported intestinal-restricted FXR agonist fexaramine (Fex). We demonstrated that Fex-3 targeted on FXR in ileum and has better selectivity than Fex. And the study of utilizing Fex-3 to reduce obesity was undergoing.